Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter

被引：123

作者：

Miyamoto, K ^{[1
]}

Shiraga, T ^{[1
]}

Morita, K ^{[1
]}

Yamamoto, H ^{[1
]}

Haga, H ^{[1
]}

Taketani, Y ^{[1
]}

Tamai, I ^{[1
]}

Sai, Y ^{[1
]}

Tsuji, A ^{[1
]}

Takeda, E ^{[1
]}

机构：

[1] KANAZAWA UNIV, FAC PHARMACEUT SCI, DEPT BIOPHARMACEUT, KANAZAWA, ISHIKAWA 920, JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1305卷 / 1-2期

关键词：

oligopeptide transporter; small intestine; (rat);

D O I：

10.1016/0167-4781(95)00208-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe. The cDNA sequence indicates that rat PepT1 is composed of 710 amino acids and shows 77% and 83% amino acid sequence identity with rabbit and human PepT1, respectively. Northern blot analysis detected rat PepT1 mRNA in the small intestine and kidney. Intestinal PepT1 mRNA levels were highest in 4-day-old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepT1 gene change markedly during development.

引用

页码：34 / 38

页数：5

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