Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

被引：128

作者：

Benedict, Christian ^{[1
]}

Byberg, Liisa ^{[2
]}

Cedernaes, Jonathan ^{[1
]}

Hogenkamp, Pleunie S. ^{[1
]}

Giedratis, Vilmantas ^{[3
]}

Kilander, Lena ^{[3
]}

Lind, Lars ^{[4
]}

Lannfelt, Lars ^{[3
]}

Schioth, Helgi B. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Neurosci, Uppsala, Sweden

[2] Uppsala Univ, Dept Surg Sci, Orthoped, Uppsala, Sweden

[3] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden

[4] Uppsala Univ, Univ Hosp, Dept Med Sci, Uppsala, Sweden

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 09期

基金：

瑞典研究理事会;

关键词：

Sleep; All-cause dementia; Alzheimer's disease; Longitudinal study; PLASMA AMYLOID-BETA; NEURON-SPECIFIC ENOLASE; DIAGNOSIS; DEMENTIA; PROTEIN; APNEA; DEGENERATION; BIOMARKERS; QUALITY; AGE;

D O I：

10.1016/j.jalz.2014.08.104

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To study the association between self-reported sleep disturbances and dementia risk. Methods: Self-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of beta-amyloid (A beta) peptides 1-40 and 1-42 were measured at ages 70, 77, and 82 years. Results: Cox regression demonstrated that men with self-reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self-reported sleep disturbances (both P < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P < .001). No group differences were found in A beta levels. Conclusion: Improving sleep quality may help reduce the neurodegenerative risk in older men. (C) 2015 The Authors. Published by Elsevier Inc.

引用

页码：1090 / 1097

页数：8

共 38 条

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