Resolution of immune haemolytic anaemia with allogeneic bone marrow transplantation after an unsuccessful autograft

被引：23

作者：

De Stefano, P

Zecca, M

Giorgiani, G

Perotti, C

Giraldi, E

Locatelli, F

机构：

[1] Univ Pavia, Policlin San Matteo, IRCCS, Dept Paediat, I-27100 Pavia, Italy

[2] Policlin San Matteo, IRCCS, Blood Transfus Serv, I-27100 Pavia, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 106卷 / 04期

关键词：

autoimmune disease; thalassaemia; immune haemolytic anaemia; bone marrow transplantation; immunosuppressive treatment;

D O I：

10.1046/j.1365-2141.1999.01658.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autologous transplantation of lymphocyte-depleted peripheral blood stem cells (PBSC) has been proposed for treatment of patients with severe autoimmune disease. However, several patients have been reported to achieve only transient remissions. We report on a child with thalassaemia intermedia and immune-mediated haemolytic anaemia, given an autologous lymphocyte-depleted PBSC transplant, who relapsed 7 weeks after transplant. A complete remission, lasting 18 months to date, was obtained with allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor. This experience indicates that, in selected cases, allogeneic BMT may be the treatment of choice for life-threatening autoimmune disease. A graft-versus-autoimmunity effect may favour the eradication of the recipient autoaggressive lymphocytes.

引用

页码：1063 / 1064

页数：2

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