Evaluating signatures of sex-specific processes in the human genome

被引:39
作者
Bustamante, Carlos D. [1 ]
Ramachandran, Sohini [2 ]
机构
[1] Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY 14850 USA
[2] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
关键词
HAPLOTYPE MAP; GENETIC DATA; MIGRATION; CHROMOSOME;
D O I
10.1038/ng0109-8
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Comparing levels of genetic variation between the X chromosome and autosomes can reveal the different demographic histories of males and females of a species. Taking this approach, two new studies report that the effective population sizes of men and women differ, but they disagree as to which sex outnumbered the other.
引用
收藏
页码:8 / 10
页数:4
相关论文
共 13 条
[1]   A haplotype map of the human genome [J].
Altshuler, D ;
Brooks, LD ;
Chakravarti, A ;
Collins, FS ;
Daly, MJ ;
Donnelly, P ;
Gibbs, RA ;
Belmont, JW ;
Boudreau, A ;
Leal, SM ;
Hardenbol, P ;
Pasternak, S ;
Wheeler, DA ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Zeng, CQ ;
Gao, Y ;
Hu, HR ;
Hu, WT ;
Li, CH ;
Lin, W ;
Liu, SQ ;
Pan, H ;
Tang, XL ;
Wang, J ;
Wang, W ;
Yu, J ;
Zhang, B ;
Zhang, QR ;
Zhao, HB ;
Zhao, H ;
Zhou, J ;
Gabriel, SB ;
Barry, R ;
Blumenstiel, B ;
Camargo, A ;
Defelice, M ;
Faggart, M ;
Goyette, M ;
Gupta, S ;
Moore, J ;
Nguyen, H ;
Onofrio, RC ;
Parkin, M ;
Roy, J ;
Stahl, E ;
Winchester, E ;
Ziaugra, L ;
Shen, Y .
NATURE, 2005, 437 (7063) :1299-1320
[2]   Accurate whole human genome sequencing using reversible terminator chemistry [J].
Bentley, David R. ;
Balasubramanian, Shankar ;
Swerdlow, Harold P. ;
Smith, Geoffrey P. ;
Milton, John ;
Brown, Clive G. ;
Hall, Kevin P. ;
Evers, Dirk J. ;
Barnes, Colin L. ;
Bignell, Helen R. ;
Boutell, Jonathan M. ;
Bryant, Jason ;
Carter, Richard J. ;
Cheetham, R. Keira ;
Cox, Anthony J. ;
Ellis, Darren J. ;
Flatbush, Michael R. ;
Gormley, Niall A. ;
Humphray, Sean J. ;
Irving, Leslie J. ;
Karbelashvili, Mirian S. ;
Kirk, Scott M. ;
Li, Heng ;
Liu, Xiaohai ;
Maisinger, Klaus S. ;
Murray, Lisa J. ;
Obradovic, Bojan ;
Ost, Tobias ;
Parkinson, Michael L. ;
Pratt, Mark R. ;
Rasolonjatovo, Isabelle M. J. ;
Reed, Mark T. ;
Rigatti, Roberto ;
Rodighiero, Chiara ;
Ross, Mark T. ;
Sabot, Andrea ;
Sankar, Subramanian V. ;
Scally, Aylwyn ;
Schroth, Gary P. ;
Smith, Mark E. ;
Smith, Vincent P. ;
Spiridou, Anastassia ;
Torrance, Peta E. ;
Tzonev, Svilen S. ;
Vermaas, Eric H. ;
Walter, Klaudia ;
Wu, Xiaolin ;
Zhang, Lu ;
Alam, Mohammed D. ;
Anastasi, Carole .
NATURE, 2008, 456 (7218) :53-59
[3]   A second generation human haplotype map of over 3.1 million SNPs [J].
Frazer, Kelly A. ;
Ballinger, Dennis G. ;
Cox, David R. ;
Hinds, David A. ;
Stuve, Laura L. ;
Gibbs, Richard A. ;
Belmont, John W. ;
Boudreau, Andrew ;
Hardenbol, Paul ;
Leal, Suzanne M. ;
Pasternak, Shiran ;
Wheeler, David A. ;
Willis, Thomas D. ;
Yu, Fuli ;
Yang, Huanming ;
Zeng, Changqing ;
Gao, Yang ;
Hu, Haoran ;
Hu, Weitao ;
Li, Chaohua ;
Lin, Wei ;
Liu, Siqi ;
Pan, Hao ;
Tang, Xiaoli ;
Wang, Jian ;
Wang, Wei ;
Yu, Jun ;
Zhang, Bo ;
Zhang, Qingrun ;
Zhao, Hongbin ;
Zhao, Hui ;
Zhou, Jun ;
Gabriel, Stacey B. ;
Barry, Rachel ;
Blumenstiel, Brendan ;
Camargo, Amy ;
Defelice, Matthew ;
Faggart, Maura ;
Goyette, Mary ;
Gupta, Supriya ;
Moore, Jamie ;
Nguyen, Huy ;
Onofrio, Robert C. ;
Parkin, Melissa ;
Roy, Jessica ;
Stahl, Erich ;
Winchester, Ellen ;
Ziaugra, Liuda ;
Altshuler, David ;
Shen, Yan .
NATURE, 2007, 449 (7164) :851-U3
[4]   Sex-Biased Evolutionary Forces Shape Genomic Patterns of Human Diversity [J].
Hammer, Michael F. ;
Mendez, Fernando L. ;
Cox, Murray P. ;
Woerner, August E. ;
Wall, Jeffrey D. .
PLOS GENETICS, 2008, 4 (09)
[5]   Accelerated genetic drift on chromosome X during the human dispersal out of Africa [J].
Keinan, Alon ;
Mullikin, James C. ;
Patterson, Nick ;
Reich, David .
NATURE GENETICS, 2009, 41 (01) :66-70
[6]   Human mtDNA and Y-chromosome variation is correlated with matrilocal versus patrilocal residence [J].
Oota, H ;
Settheetham-Ishida, W ;
Tiwawech, D ;
Ishida, T ;
Stoneking, M .
NATURE GENETICS, 2001, 29 (01) :20-21
[7]   Population differentiation and migration: Coalescence times in a two-sex island model for autosomal and X-linked loci [J].
Ramachandran, Sohini ;
Rosenberg, Noah A. ;
Feldman, Marcus W. ;
Wakeley, John .
THEORETICAL POPULATION BIOLOGY, 2008, 74 (04) :291-301
[8]   The X chromosome in population genetics [J].
Schaffner, SF .
NATURE REVIEWS GENETICS, 2004, 5 (01) :43-51
[9]   Sex-Specific Genetic Structure and Social Organization in Central Asia: Insights from a Multi-Locus Study [J].
Segurel, Laure ;
Martinez-Cruz, Begona ;
Quintana-Murci, Lluis ;
Balaresque, Patricia ;
Georges, Myriam ;
Hegay, Tatiana ;
Aldashev, Almaz ;
Nasyrova, Firuza ;
Jobling, Mark A. ;
Heyer, Evelyne ;
Vitalis, Renaud .
PLOS GENETICS, 2008, 4 (09)
[10]   Genetic evidence for a higher female migration rate in humans [J].
Seielstad, MT ;
Minch, E ;
Cavalli-Sforza, LL .
NATURE GENETICS, 1998, 20 (03) :278-280