Immunohistochemical staining of endomorphin 1 and 2 in the immune cells of the spleen

被引：18

作者：

Seale, JV ^{[1
]}

Jessop, DS ^{[1
]}

Harbuz, MS ^{[1
]}

机构：

[1] Lab Integrat Neurosci & Endocrinol, Bristol BS1 3NY, Avon, England

来源：

PEPTIDES | 2004年 / 25卷 / 01期

关键词：

endomorphin; spleen; immunohistochemistry; macrophages; B cells; T cells; gender;

D O I：

10.1016/j.peptides.2003.11.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research, has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for EMs in this area. The current study examines the localization of EM-1 and -2 in the immune cells of the spleen of male and female rats via an immumohistochemical procedure. In both genders, E-M-1 and -2 immunoreactive staining was predominantly present in macrophages and B cells with minimal EM immumoreactive staining in T cells. This is the first evidence of a differential distribution of EM-1 and -2 in cells of the immune system. (C) 2004 Published by Elsevier Inc.

引用

页码：91 / 94

页数：4

共 17 条

[1] Endomorphin-2 modulates productions of TNF-α, IL-1β, IL-10, and IL-12, and alters functions related to innate immune of macrophages [J].

Azuma, Y ;

Ohura, K .

INFLAMMATION, 2002, 26 (05) :223-232

[2] THE SYNTAX OF IMMUNE-NEUROENDOCRINE COMMUNICATION [J].

BLALOCK, JE .

IMMUNOLOGY TODAY, 1994, 15 (11) :504-511

[3] OPIOID-PEPTIDES MODULATE PRODUCTION OF INTERFERON-GAMMA BY HUMAN MONONUCLEAR-CELLS [J].

BROWN, SL ;

VANEPPS, DE .

CELLULAR IMMUNOLOGY, 1986, 103 (01) :19-26

[4] MU-OPIOID RECEPTOR GENE-EXPRESSION IN IMMUNE CELLS [J].

CHUANG, TK ;

KILLAM, KF ;

CHUANG, LF ;

KUNG, HF ;

SHENG, WS ;

CHAO, CC ;

YU, L ;

CHUANG, RY .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 216 (03) :922-930

[5] IMMUNOREACTIVE DYNORPHIN IS REGULATED BY ESTROGEN IN THE RAT ANTERIOR-PITUITARY [J].

FULLERTON, MJ ;

SMITH, AI ;

FUNDER, JW .

NEUROENDOCRINOLOGY, 1988, 47 (01) :1-6

[6]

Grossman C. J., 1990, PROG NEUROENDOCRINIM, V3, P75

[7] DYNORPHIN, A PREFERENTIAL LIGAND FOR KAPPA-OPIOID RECEPTORS, IS PRESENT IN NERVE-FIBERS AND IMMUNE CELLS WITHIN INFLAMED TISSUE OF THE RAT [J].

HASSAN, AHS ;

PZEWLOCKI, R ;

HERZ, A ;

STEIN, C .

NEUROSCIENCE LETTERS, 1992, 140 (01) :85-88

[8] SEX STEROIDS, GLUCOCORTICOIDS, STRESS AND AUTOIMMUNITY [J].

HOMODELARCHE, F ;

FITZPATRICK, F ;

CHRISTEFF, N ;

NUNEZ, EA ;

BACH, JF ;

DARDENNE, M .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1991, 40 (4-6) :619-637

[9] Endomorphin-1 and endomorphin-2:: pharmacology of the selective endogenous μ-opioid receptor agonists [J].

Horvath, G .

PHARMACOLOGY & THERAPEUTICS, 2000, 88 (03) :437-463

[10] Novel opioid peptides endomorphin-1 and endomorphin-2 are present in mammalian immune tissues [J].

Jessop, DS ;

Major, GN ;

Coventry, TL ;

Kaye, SJ ;

Fulford, AJ ;

Harbuz, MS ;

De Bree, FM .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 106 (1-2) :53-59

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