Ghrelin immunohistochemistry of gastric adenocarcinoma and mucoepidermoid carcinoma of salivary gland

被引：35

作者：

Aydin, S ^{[1
]}

Ozercan, IH

Dagli, F

Aydin, S ^{[1
]}

Dogru, O

Celebi, S

Akin, O

Guzel, SP

机构：

[1] Firat Univ, Dept Biochem & Clin Biochem, Sch Med, TR-23119 Elazig, Turkey

[2] Firat Univ, Dept Pathol, Sch Med, TR-23119 Elazig, Turkey

[3] Firat Univ, Dept Med Educ, Sch Med, TR-23119 Elazig, Turkey

[4] Firat Univ, Dept Gen Surg, Sch Med, TR-23119 Elazig, Turkey

[5] Firat Univ, Dept Gastroenterol, Sch Med, TR-23119 Elazig, Turkey

[6] Lady Zubeyde Mat Ward, Dept Biochem & Clin Biochem, Ankara, Turkey

[7] Bingol State Hosp, Biochem Lab, Bingol, Turkey

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2005年 / 80卷 / 3-4期

关键词：

gastric cancer; ghrelin; immunohistochemistry; mucoepidermoid carcinoma; salivary gland;

D O I：

10.1080/10520290500387847

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ghrelin (G-HH) synthesized in several tissues including salivary and stomach glands stimulates appetite in humans by modulating neuropeptide Y neurons in the hypothalamic arcuate nucleus. Loss of appetite is one of the most important symptoms of stomach cancer. We conducted a study using immunohistochemistry to determine whether salivary glands and stomach cancer tissues produce ghrelin. We determined that negative ghrelin immunohistochemistry discriminates tumors from normal tissues and may therefore further our understanding of the clinically important problem of reduced food intake and anorexia in cancer patients. Radioimmunoassay analyses confirmed that cancer cells do not produce a G-HH peptide, whereas normal cells yield this peptide.

引用

页码：163 / 168

页数：6

共 29 条

[1] Gastric cancer: epidemiology, pathology and treatment [J].

Alberts, SR ;

Cervantes, A ;

van de Velde, CJH .

ANNALS OF ONCOLOGY, 2003, 14 :31-36

[2] A comparison of leptin and ghrelin levels in plasma and saliva of young healthy subjects [J].

Aydin, S ;

Halifeoglu, I ;

Ozercan, IH ;

Erman, F ;

Kilic, N ;

Aydin, S ;

Ilhan, N ;

Ozkan, Y ;

Akpolat, N ;

Sert, L ;

Caylak, E .

PEPTIDES, 2005, 26 (04) :647-652

[3] Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines [J].

Cassoni, P ;

Ghé, C ;

Marrocco, T ;

Tarabra, E ;

Allia, E ;

Catapano, F ;

Deghenghi, R ;

Ghigo, E ;

Papotti, M ;

Muccioli, G .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2004, 150 (02) :173-184

[4] Circulating levels of ghrelin in human fetuses [J].

Cortelazzi, D ;

Cappiello, V ;

Morpurgo, PS ;

Ronzoni, S ;

De Santis, MSN ;

Cetin, I ;

Beck-Peccoz, P ;

Spada, A .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 149 (02) :111-116

[5]

De Ambrogi M, 2003, MED SCI MONITOR, V9, P217

[6]

Espelund U, 2003, APMIS, V111, P140

[7]

FARLEY DR, 1992, SURG CLIN N AM, V72, P401

[8] Serum ghrelin levels in acromegaly: Effects of surgical and long-acting octreotide therapy [J].

Freda, PU ;

Reyes, CM ;

Conwell, IM ;

Sundeen, RE ;

Wardlaw, SL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (05) :2037-2044

[9] Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors [J].

Gaytan, F ;

Barreiro, ML ;

Caminos, JE ;

Chopin, LK ;

Herington, AC ;

Morales, C ;

Pinilla, L ;

Paniagua, R ;

Nistal, M ;

Casanueva, FF ;

Aguilar, E ;

Diéguez, C ;

Tena-Sempere, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (01) :400-409

[10] The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans [J].

Gnanapavan, S ;

Kola, B ;

Bustin, SA ;

Morris, DG ;

McGee, P ;

Fairclough, P ;

Bhattacharya, S ;

Carpenter, R ;

Grossman, AB ;

Korbonits, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (06) :2988-2991

← 1 2 3 →