Dendritic cell-based cancer vaccination:: quo vadis?

被引：17

作者：

Dauer, M. ^{[1
]}

Schnurr, M. ^{[1
]}

Eigler, A. ^{[1
]}

机构：

[1] Saarland Univ Hosp, Dept Gastroenterol Hepatol & Endocrinol, Med Klin 2, D-66421 Homburg, Germany

来源：

EXPERT REVIEW OF VACCINES | 2008年 / 7卷 / 07期

关键词：

adjuvant; cancer vaccine; chemotherapy; cytotoxic T cell; dendritic cell; immunomonitoring; monocyte;

D O I：

10.1586/14760584.7.7.1041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) play a central role in the initiation and regulation of primary immune responses. DCs loaded with tumor-associated antigens induce anti-tumoral cytotoxic T cells in vitro and in vivo. However, clinical trials using ex vivo-generated DCs have failed to demonstrate clinical efficacy. This review summarizes recent advances in concepts and techniques that are providing new impulses to DC-based cancer vaccination. Improvements in protocols for ex vivo-generation of DCs, innovations in immunomonitoring, strategies to overcome tumor-induced immunosuppression and insights into the mutual beneficial effects of vaccines and chemotherapy are all considered. Furthermore, we highlight novel developments in cell-free vaccines targeting DCs in vivo.

引用

收藏

页码：1041 / 1053

页数：13

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