Development and regulation of dendritic spine synapses

被引：200

作者：

Calabrese, B ^{[1
]}

Wilson, MS

Halpain, S

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA

来源：

PHYSIOLOGY | 2006年 / 21卷

关键词：

D O I：

10.1152/physiol.00042.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.

引用

页码：38 / 47

页数：10

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