Genetically engineered resistance to dengue-2 virus transmission in mosquitoes

被引：149

作者：

Olson, KE

Higgs, S

Gaines, PJ

Powers, AM

Davis, BS

Kamrud, KI

Carlson, JO

Blair, CD

Beaty, BJ

机构：

[1] Arthropod-Borne Infect. Dis. Lab., Department of Microbiology, Colorado State University, Fort Collins

来源：

SCIENCE | 1996年 / 272卷 / 5263期

关键词：

D O I：

10.1126/science.272.5263.884

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The control of arthropod-borne virus diseases such as dengue may ultimately require the genetic manipulation of mosquito vectors to disrupt virus transmission to human populations. To reduce the ability of mosquitoes to transmit dengue viruses, a recombinant Sindbis virus was used to transduce female Aedes aegypti with a 567-base antisense RNA targeted to the premembrane coding region of dengue type 2 (DEN-2) virus. The transduced mosquitoes were unable to support replication of DEN-P virus in their salivary glands and therefore were not able to transmit the virus.

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页码：884 / 886

页数：3

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