Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli

被引：246

作者：

Roitman, Mitchell F. ^{[1
]}

Wheeler, Robert A. ^{[2
]}

Wightman, R. Mark ^{[3
,4
,5
]}

Carelli, Regina M. ^{[2
,4
,5
]}

机构：

[1] Univ Illinois, Dept Psychol, Chicago, IL 60607 USA

[2] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 12期

关键词：

D O I：

10.1038/nn.2219

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.

引用

页码：1376 / 1377

页数：2

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