Nickel-Catalyzed Oxidative Coupling Reactions of Two Different Terminal Alkynes Using O2 as the Oxidant at Room Temperature: Facile Syntheses of Unsymmetric 1,3-Diynes

被引：252

作者：

Yin, Weiyan ^{[1
]}

He, Chuan ^{[1
]}

Chen, Mao ^{[1
]}

Zhang, Heng ^{[1
]}

Lei, Aiwen ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

HOMOCOUPLING REACTION; DIOXYGEN ACTIVATION; MOLECULAR-OXYGEN; SELECTIVE OXIDATION; EFFICIENT CATALYSTS; ORGANIC-CHEMICALS; AEROBIC OXIDATION; PALLADIUM; COMPLEXES; ALCOHOLS;

D O I：

10.1021/ol8027863

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two different terminal alkynes now can be coupled together in the presence of NiCl2 center dot 6H(2)O/Cul by using an excess of one of the terminal alkyne substrates. The new method employed 20 mol % TMEDA as the ligand and environmentally benign O-2 or air as the oxidant. It is the first example using Ni-salt as catalyst by employing air or O-2 as oxidant, which led to efficient heterocoupling of two different alkynes.

引用

页码：709 / 712

页数：4

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