Regulation of mRNA translation by protein folding in the endoplasmic reticulum

被引：124

作者：

Kaufman, RJ ^{[1
]}

机构：

[1] Univ Michigan, Ctr Med, Dept Biol Chem, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.tibs.2004.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The process of protein secretion is intimately linked to the rate and potential of proper folding and assembly of secretory proteins. The efficiency of protein folding is communicated to the cytoplasm via several signal transduction pathways. This regulates the rate of polypeptide chain synthesis and induction of genes encoding functions that reduce protein-folding load on the endoplasmic reticulum (ER). This review summarizes recent insights into the mechanisms that couple protein translation with protein folding in the ER.

引用

页码：152 / 158

页数：7

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