Intracerebral activity of antibiotics against Listeria monocytogenes during experimental rhombencephalitis

被引：10

作者：

Blanot, S ^{[1
]}

Boumaila, C ^{[1
]}

Berche, P ^{[1
]}

机构：

[1] Fac Med Necker, Microbiol Lab, INSERM, U411, F-75730 Paris 15, France

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 44卷 / 04期

关键词：

D O I：

10.1093/jac/44.4.565

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We used a model of rhombencehalitis in gerbils to test the efficacy of various antibiotics against Listeria monocytogenes. Gerbils were inoculated in the middle ear with strain EGD and treated subcutaneously with various antibiotics alone or in combination. We found that the most active antibiotics on intracerebral bacteria were amoxycillin, co-trimoxazole, rifampicin and imipenem. Vancomycin, gentamicin and ciprofloxacin were weakly or not active. The combinations amoxycillin-co-trimoxazole, amoxycillin-gentamicin and co-trimoxazol-rifampicin were highly active against intracerebral bacteria.

引用

页码：565 / 568

页数：4

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