Synthesis of the 2β,3β-, 2α,3β-, 2β,3α- and 2α,3α- isomers of 6β-hydroxy-3-(p-tolyl)tropane-2-carboxylic acid methyl ester

被引：9

作者：

Zhao, LY ^{[1
]}

Kozikowski, AP ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Drug Discovery Program, Inst Cognit & Computat Sci, Washington, DC 20007 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(99)00869-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Hydroxytropanone (8) was synthesized by a Mannich type condensation between acetonedicarboxylic acid, methylamine hydrochloride, and the hydrolysis product of 2,5-dimethoxydihydrofuran and was used as the key intermediate for the synthesis of the four racemic isomers of 6 beta-hydroxy-2-(methoxycarbonyl)-3-(p-tolyl)tropane. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4961 / 4964

页数：4

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