ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry

被引：79

作者：

Sleiman, Patrick M. A. ^{[1
]}

Annaiah, Kiran ^{[1
]}

Imielinski, Marcin ^{[1
]}

Bradfield, Jonathan P. ^{[1
]}

Kim, Cecilia E. ^{[1
]}

Frackelton, Edward C. ^{[1
]}

Glessner, Joseph T. ^{[1
]}

Eckert, Andrew W. ^{[1
]}

Otieno, F. George ^{[1
]}

Santa, Erin ^{[1
]}

Thomas, Kelly ^{[1
]}

Smith, Ryan M. ^{[1
]}

Glaberson, Wendy ^{[1
]}

Garris, Maria ^{[1
]}

Gunnlaugsson, Sigfus ^{[1
]}

Chiavacci, Rosetta M. ^{[1
]}

Allen, Julian ^{[2
]}

Spergel, Jonathan ^{[3
]}

Grundmeier, Robert ^{[4
]}

Grunstein, Michael M. ^{[2
]}

Magnusson, Mark ^{[5
]}

Bisgaard, Hans ^{[6
]}

Grant, Struan F. A. ^{[1
,5
]}

Hakonarson, Hakon ^{[1
,2
,5
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Ctr Appl Genom,Div Human Genet, Philadelphia, PA 19104 USA

[2] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Pulm Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Allergy & Immunol, Philadelphia, PA 19104 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Bioinformat, Philadelphia, PA 19104 USA

[5] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[6] Univ Copenhagen, Dept Hlth Sci, Copenhagen, Denmark

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2008年 / 122卷 / 06期

关键词：

D O I：

10.1016/j.jaci.2008.06.041

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：1225 / 1227

页数：3

共 9 条

[1]

CHANYEUNG M, 1993, AM REV RESPIR DIS, V147, P1056

[2]

Falush D, 2003, GENETICS, V164, P1567

[3] ORMDL3 gene is associated with asthma in three ethnically diverse populations [J].

Galanter, Joshua ;

Choudhry, Shweta ;

Eng, Celeste ;

Nazario, Sylvette ;

Rodriguez-Santana, Jose R. ;

Casal, Jesus ;

Torres-Palacios, Alfonso ;

Salas, Jorge ;

Chapela, Rocio ;

Watson, H. Geoffrey ;

Meade, Kelley ;

LeNoir, Michael ;

Rodriguez-Cintron, William ;

Avila, Pedro C. ;

Burchard, Esteban Gonzalez .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (11) :1194-1200

[4] A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene [J].

Hakonarson, Hakon ;

Grant, Struan F. A. ;

Bradfield, Jonathan P. ;

Marchand, Luc ;

Kim, Cecilia E. ;

Glessner, Joseph T. ;

Grabs, Rosemarie ;

Casalunovo, Tracy ;

Taback, Shayne P. ;

Frackelton, Edward C. ;

Lawson, Margaret L. ;

Robinson, Luke J. ;

Skraban, Robert ;

Lu, Yang ;

Chiavacci, Rosetta M. ;

Stanley, Charles A. ;

Kirsch, Susan E. ;

Rappaport, Eric F. ;

Orange, Jordan S. ;

Monos, Dimitri S. ;

Devoto, Marcella ;

Qu, Hui-Qi ;

Polychronakos, Constantin .

NATURE, 2007, 448 (7153) :591-U7

[5] ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins [J].

Hjelmqvist, Lars ;

Tuson, Miquel ;

Marfany, Gemma ;

Herrero, Enric ;

Balcells, Susana ;

Gonzalez-Duarte, Roser .

GENOME BIOLOGY, 2002, 3 (06)

[6] Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma [J].

Moffatt, Miriam F. ;

Kabesch, Michael ;

Liang, Liming ;

Dixon, Anna L. ;

Strachan, David ;

Heath, Simon ;

Depner, Martin ;

von Berg, Andrea ;

Bufe, Albrecht ;

Rietschel, Ernst ;

Heinzmann, Andrea ;

Simma, Burkard ;

Frischer, Thomas ;

Willis-Owen, Saffron A. G. ;

Wong, Kenny C. C. ;

Illig, Thomas ;

Vogelberg, Christian ;

Weiland, Stephan K. ;

von Mutius, Erika ;

Abecasis, Goncalo R. ;

Farrall, Martin ;

Gut, Ivo G. ;

Lathrop, G. Mark ;

Cookson, William O. C. .

NATURE, 2007, 448 (7152) :470-U5

[7]

NEWMANTAYLOR A, 1995, LANCET, V345, P296, DOI 10.1016/S0140-6736(95)90280-5

[8] Asthma genetics 2006: the long and winding road to gene discovery [J].

Ober, C ;

Hoffjan, S .

GENES AND IMMUNITY, 2006, 7 (02) :95-100

[9] A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications [J].

Tavendale, Roger ;

Macgregor, Donald F. ;

Mukhopadhyay, Somnath ;

Palmer, Colin N. A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (04) :860-863

← 1 →