p16INK4a immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia

被引：23

作者：

Dalle, JH

Fournier, M

Nelken, B

Mazingue, F

Laï, JL

Bauters, F

Fenaux, P

Quesnel, B

机构：

[1] CHU Lille, Serv Malad Sang, F-59037 Lille, France

[2] CHU Lille, Serv Hematol Pediat, F-59037 Lille, France

[3] CHU Lille, Hematol Lab, F-59037 Lille, France

[4] CHU Lille, Lab Cytogenet, F-59037 Lille, France

[5] Inst Rech Canc Lille, INSERM Unite 524, Lille, France

来源：

BLOOD | 2002年 / 99卷 / 07期

关键词：

D O I：

10.1182/blood.V99.7.2620

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the prognostic value of p16(INK4a) immunocytochemistry (ICC) analysis in 126 cases of newly diagnosed childhood acute lymphoblastic leukemia (ALL). The incidence of negative p16(INK4a) ICC was 38.1% and was more frequent in T-lineage ALL. Overall survival (OS) and event-free survival (EFS) were significantly higher in patients with positive p16(INK4a) ICC than in patients with negative ICC (6 years OS, 90% versus 63%, P=.0014; 6 years EFS, 77.8% versus 55%, P=.0033). The p16(INK4a) ICC remained a significant prognostic factor within the subgroup of B-precursor ALL. Multivariate analysis showed that negative p16(INK4a) ICC was an independent prognostic factor for OS (relative risk [RR], 3.38; P=.02) and EFS (RR, 2.49; P=.018). Sequential study showed that p16(lNK4a) expression remained stable during first relapse in most patients. These findings indicate that p16(INK4a) ICC Is an Independent factor of outcome in childhood ALL. (C) 2002 by The American Society of Hematology.

引用

页码：2620 / 2623

页数：4

共 24 条

[1] The cell cycle inhibitor p16INK4A sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels [J].