Endothelial dysfunction: Causes and consequences in patients with diabetes mellitus

被引：67

作者：

Avogaro, Angelo ^{[1
]}

de Kreutzenberg, Saula Vigili ^{[1
]}

Fadini, GianPaolo ^{[1
]}

机构：

[1] Univ Padua, Sch Med, Dept Clin & Expt Med, Padua, Italy

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2008年 / 82卷

关键词：

Diabetes; Endothelium; Oxidative stress; Endothelium progenitor cells;

D O I：

10.1016/j.diabres.2008.09.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular endothelium plays a major role in maintaining cardiovascular homeostasis. Nitric oxide is the most powerful vasodilating compound. Diabetes disrupts endothelial integrity through an increased oxidative stress. Recent evidence indicates that there is a strong interaction between diabetes, the secretory proteins of adipocytes, called adipokines, and endothelium. Endothelial dysfunction may precede the development of overt DM, and a prolonged and repeated exposure to postprandial hyperglycemia may play an important role in the development of atherosclerosis, even in those who have normal fasting plasma glucose levels. (C) 2008 Published by Elsevier Ireland Ltd.

引用

页码：S94 / S101

页数：8

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