Comparison of optimization methods for fed-batch cultures of hybridoma cells

被引：29

作者：

Roubos, JA ^{[1
]}

deGooijer, CD ^{[1
]}

vanStraten, G ^{[1
]}

vanBoxtel, AJB ^{[1
]}

机构：

[1] AGR UNIV WAGENINGEN,DEPT AGR ENGN & PHYS,NL-6703 HD WAGENINGEN,NETHERLANDS

来源：

BIOPROCESS ENGINEERING | 1997年 / 17卷 / 02期

关键词：

Dynamic Programming; Gradient Method; Computational Effort; Suitable Method; Programming Approach;

D O I：

10.1007/s004490050360

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming approach which has been presented in a previous paper [1] as the most suitable method.

引用

页码：99 / 102

页数：4