Hearing - Tightrope act

被引:38
作者
Corey, DP
Sotomayor, M
机构
[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
[3] Univ Illinois, Beckman Inst, Dept Phys, Urbana, IL 61801 USA
[4] Univ Illinois, Beckman Inst, Theoret & Computat Biophys Grp, Urbana, IL 61801 USA
关键词
D O I
10.1038/428901a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A component of the ‘tip link’ that conveys tension to mechanically sensitive ion channels in the inner ear has been identified. The finding raises new questions about elastic elements in our hearing apparatus.
引用
收藏
页码:901 / 903
页数:3
相关论文
共 13 条
  • [1] Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle
    Boëda, B
    El-Amraoui, A
    Bahloul, A
    Goodyear, R
    Daviet, L
    Blanchard, S
    Perfettini, I
    Fath, KR
    Shorte, S
    Reiners, J
    Houdusse, A
    Legrain, P
    Wolfrum, U
    Richardson, G
    Petit, C
    [J]. EMBO JOURNAL, 2002, 21 (24) : 6689 - 6699
  • [2] C-cadherin ectodomain structure and implications for cell adhesion mechanisms
    Boggon, TJ
    Murray, J
    Chappuis-Flament, S
    Wong, E
    Gumbiner, BM
    Shapiro, L
    [J]. SCIENCE, 2002, 296 (5571) : 1308 - 1313
  • [3] Goodyear RJ, 2003, J NEUROSCI, V23, P4878
  • [4] Hypothesis: A helix of ankyrin repeats of the NOMPIC-TRP ion channel is the gating spring of mechanoreceptors
    Howard, J
    Bechstedt, S
    [J]. CURRENT BIOLOGY, 2004, 14 (06) : R224 - R226
  • [5] COMPLIANCE OF THE HAIR BUNDLE ASSOCIATED WITH GATING OF MECHANOELECTRICAL TRANSDUCTION CHANNELS IN THE BULLFROGS SACCULAR HAIR CELL
    HOWARD, J
    HUDSPETH, AJ
    [J]. NEURON, 1988, 1 (03) : 189 - 199
  • [6] High-resolution structure of hair-cell tip links
    Kachar, B
    Parakkal, M
    Kurc, M
    Zhao, Y
    Gillespie, PG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) : 13336 - 13341
  • [7] Crystal structure of a 12 ANK repeat stack from human ankyrinR
    Michaely, P
    Tomchick, DR
    Machius, M
    Anderson, RGW
    [J]. EMBO JOURNAL, 2002, 21 (23) : 6387 - 6396
  • [8] Genetic analysis of vertebrate sensory hair cell mechanosensation:: the zebrafish circler mutants
    Nicolson, T
    Rüsch, A
    Friedrich, RW
    Granato, M
    Ruppersberg, JP
    Nüsslein-Volhard, C
    [J]. NEURON, 1998, 20 (02) : 271 - 283
  • [9] NompC TRP channel required for vertebrate sensory hair cell mechanotransduction
    Sidi, S
    Friedrich, RW
    Nicolson, T
    [J]. SCIENCE, 2003, 301 (5629) : 96 - 99
  • [10] Cadherin 23 is a component of the tip link in hair-cell stereocilia
    Siemens, J
    Lillo, C
    Dumont, RA
    Reynolds, A
    Williams, DS
    Gillespie, PG
    Müller, U
    [J]. NATURE, 2004, 428 (6986) : 950 - 955