Cationic bis(oxazoline)Cu(II) Lewis acid catalysts. Application to the asymmetric synthesis of ent-Delta(1)-tetrahydrocannabinol

被引：61

作者：

Evans, DA

Shaughnessy, EA

Barnes, DM

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00609-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Diels-Alder reaction of acryloyl oxazolidinone and 1-acetoxy-3-methylbutadiene is catalyzed by the cationic bis(oxazoline)Cu(II) complex 4 in high enantioselectivity. The cycloadduct is converted to ent-Delta(1)-tetrahydrocannabinol (THC) in four steps. (C) 1997 Elsevier Science Ltd.

引用

页码：3193 / 3194

页数：2

共 16 条

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