Multiple roles of the tumor suppressor p53

被引：310

作者：

Bargonetti, J ^{[1
]}

Manfredi, JJ

机构：

[1] CUNY Hunter Coll, Dept Biol, Inst Biomol Struct & Funct, New York, NY 10021 USA

[2] CUNY, Grad Sch, New York, NY USA

[3] CUNY Mt Sinai Sch Med, Derald H Rutterberg Canc Ctr, New York, NY 10029 USA

来源：

CURRENT OPINION IN ONCOLOGY | 2002年 / 14卷 / 01期

关键词：

D O I：

10.1097/00001622-200201000-00015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor suppressor p53 controls numerous downstream targets that can result in variable outcomes, including apoptosis, transient growth arrest, and sustained growth arrest or senescence. The activation of p53, followed by its ability to play multiple roles in the control of genomic integrity or the elimination of damaged or tumorigenic cells, is performed by a complex process of cross-talk orchestrated to occur in the different compartments of the cell. Controlling performance of the many roles of p53 is a goal of many research groups and the focus of this review. (C) 2002 Lippincott Williams Wilkins. Inc.

引用

页码：86 / 91

页数：6

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