IMPROVEMENT OF BRAIN TISSUE OXYGENATION BY INHALATION OF CARBOGEN

被引:47
作者
Ashkanian, M. [1 ,2 ]
Borghammer, P. [1 ,3 ]
Gjedde, A. [1 ,3 ]
Ostergaard, L. [1 ,2 ]
Vafaee, M. [1 ,3 ]
机构
[1] Aarhus Univ, Aarhus Univ Hosp, Ctr Functionally Integrat Neurosci, DK-8000 Aarhus C, Denmark
[2] Aarhus Univ Hosp, Dept Neuroradiol, DK-8000 Aarhus, Denmark
[3] Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark
基金
新加坡国家研究基金会; 英国医学研究理事会;
关键词
oxygen; carbogen; brain tissue oxygenation; CBF; OEF;
D O I
10.1016/j.neuroscience.2008.08.016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5% CO2 is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO2) during inhalation of test gases (O-2, CO2, carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO2 or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO2 generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (SaO(2)). The present data demonstrate that inhalation of carbogen increases both CBF and SaO(2) in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and SaO(2). (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:932 / 938
页数:7
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