Risk and natural history of colonic neoplasia in patients with primacy sclerosing cholangitis and ulcerative colitis

被引:253
作者
Brentnall, TA
Haggitt, RC
Rabinovitch, PS
Kimmey, MB
Bronner, MP
Levine, DS
Kowdley, KV
Stevens, AC
Crispin, DA
Emond, M
Rubin, CE
机构
[1] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT BIOSTAT,SEATTLE,WA 98195
关键词
INFLAMMATORY BOWEL-DISEASE; DNA ANEUPLOIDY; CANCER SURVEILLANCE; DYSPLASIA; HISTOLOGY; FEATURES;
D O I
10.1053/gast.1996.v110.pm8566577
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aims: Primary sclerosing cholangitis (PSC) has been suggested as a risk factor for the development of colorectal cancer in ulcerative colitis (UC); however, previous studies of this association have been limited by small numbers of patients with PSC or have been performed retrospectively. This study prospectively evaluates the risk and natural history of colonic tumorigenesis in patients with PSC and UC and compares it with patients with UC without PSC. Methods: Twenty patients with PSC and UC and 25 control patients with UC were followed prospectively by colonoscopic surveillance using extensive mucosal biopsy sampling. All control patients with UC had disease extending beyond the sigmoid colon of greater than or equal to 8 years' duration; patients with PSC and UC were studied regardless of disease duration. Results: Forty-five percent (9 of 20) of the patients with PSC and UC had dysplasia compared with 16% (4 of 25) of the control patients with UC (P less than or equal to 0.002). Prior liver transplantation did not affect the risk of colonic dysplasia. The time course for progression to dysplasia was similar between the patients with PSC and UC and the patients with UC; however, the patients with PSC and UC were five times more likely to develop dysplasia. Conclusions: Patients with PSC and UC represent a subset of patients with UC who are at markedly increased risk for colonic neoplasia and who need close colonoscopic surveillance with extensive biopsy sampling.
引用
收藏
页码:331 / 338
页数:8
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