Peroxiredoxin I expression in human thyroid tumors

被引：107

作者：

Yanagawa, T

Ishikawa, T

Ishii, T

Tabuchi, K

Iwasa, S

Bannai, S

Omura, K

Suzuki, H

Yoshida, H

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Oral & Maxillofacial Surg, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Inst Basic Med Sci, Dept Pathol, Tsukuba, Ibaraki 3058575, Japan

[3] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Mol Genet, Dallas, TX 75235 USA

[4] Univ Tsukuba, Inst Basic Med Sci, Dept Biochem, Tsukuba, Ibaraki 3058575, Japan

[5] Tukuba Gakuen Hosp, Tsukuba, Ibaraki, Japan

[6] Chiba Canc Ctr Hosp, Div Head & Neck Surg, Chiba, Japan

来源：

CANCER LETTERS | 1999年 / 145卷 / 1-2期

关键词：

thioredoxin peroxidase; peroxiredoxin; MSP23; proliferating associated gene; oxidative stress;

D O I：

10.1016/S0304-3835(99)00243-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression levels in follicular neoplasm (P = 0.00005) and thyroiditis group (P = 0.0037) were significantly higher than that of the control group, while papillary carcinoma group did not show statistical significance, Immunohistochemistry indicated that Pn; I was in epithelial cells of thyroid follicles. These results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：127 / 132

页数：6

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