Plasma Biomarkers of Oxidative Stress in Neonatal Brain Injury

被引：57

作者：

Tataranno, Maria Luisa ^{[1
]}

Perrone, Serafina ^{[1
]}

Buonocore, Giuseppe ^{[1
]}

机构：

[1] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy

来源：

CLINICS IN PERINATOLOGY | 2015年 / 42卷 / 03期

关键词：

Oxidative stress; Newborn infant; Brain damage; Plasma biomarkers; Lipid peroxidation; Inflammation; Hypoxia-ischemia; NITRIC-OXIDE SYNTHASE; PROTEIN-BOUND IRON; HYPOXIA-ISCHEMIA; PREDICTIVE MARKER; AMNIOTIC-FLUID; DAMAGE; MODEL; INFLAMMATION; MECHANISMS; EXPRESSION;

D O I：

10.1016/j.clp.2015.04.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Perinatal encephalopathy is a leading cause of lifelong disability. Increasing evidence indicates that the pathogenesis of perinatal brain damage is much more complex than originally thought, with multiple pathways involved. An important role of oxidative stress (OS) in the pathogenesis of brain injury is recognized for preterm and term infants. This article examines potential reliable and specific OS biomarkers that can be used in premature and term infants for the early detection and follow-up of the most common neonatal brain injuries, such as hypoxic-ischemic encephalopathy, intraventricular hemorrhage, and periventricular leukomalacia. The next step will be to explore the correlation between brain-specific OS biomarkers and functional brain outcomes.

引用

页码：529 / +

页数：12

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