Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion-Transporting Polypeptides

被引：53

作者：

Dolton, M. J. ^{[1
]}

Roufogalis, B. D. ^{[1
]}

McLachlan, A. J. ^{[1
,2
]}

机构：

[1] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia

[2] Concord Repatriat Gen Hosp, Ctr Educ & Res Ageing, Concord, Australia

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 05期

关键词：

EFFECTIVE RENIN INHIBITOR; MESSENGER-RNA EXPRESSION; FORTIFIED ORANGE JUICE; HUMAN INTESTINAL-TRACT; GRAPEFRUIT JUICE; P-GLYCOPROTEIN; PLASMA-CONCENTRATIONS; OATP-B; CACO-2; CELLS; APPLE JUICE;

D O I：

10.1038/clpt.2012.159

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Grapefruit juice is widely recognized to cause important drug interactions via inhibition of CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in enterocytes known as organic anion-transporting polypeptides (OATPs). Fruit juice coadministration significantly reduces the oral bioavailability of numerous important medicines relying on this anion transporter pathway for absorption. This article reviews the current literature on interactions between clinically used OATP substrates and fruit juice consumption.

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收藏

页码：622 / 630

页数：9

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