Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer

被引：209

作者：

Iseki, Yasuhito ^{[1
]}

Shibutani, Masatsune ^{[1
]}

Maeda, Kiyoshi ^{[1
]}

Nagahara, Hisashi ^{[1
]}

Ohtani, Hiroshi ^{[1
]}

Sugano, Kenji ^{[1
]}

Ikeya, Tetsuro ^{[1
]}

Muguruma, Kazuya ^{[1
]}

Tanaka, Hiroaki ^{[1
]}

Toyokawa, Takahiro ^{[1
]}

Sakurai, Katsunobu ^{[1
]}

Hirakawa, Kosei ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Osaka 558, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 07期

关键词：

DENSITY-LIPOPROTEIN-RECEPTOR; CLINICAL UNDERNUTRITION; CHOLESTEROL LEVELS; SERUM-CHOLESTEROL; TUMOR; RESECTION; ALBUMIN; LYMPHOCYTES; CARCINOMAS; EXPRESSION;

D O I：

10.1371/journal.pone.0132488

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background Recently, the preoperative immune-nutritional status has been reported to correlate with the survival rate in patients with colorectal cancer (CRC). However, there have been no reports on the relationship between the controlling nutritional status (CONUT) score and the clinical outcome after curative surgery for CRC. We herein evaluated the prognostic significance of the CONUT score in patients with CRC, and then compared the accuracy of the CONUT score and the prognostic nutritional index (PNI) as a predictor of survival. Methods We retrospectively reviewed a database of 204 patients who underwent curative surgery for Stage II/ III CRC. Patients were divided into two groups according to the CONUT score and the PNI. Results The five-year cancer-specific survival (CSS) rate was significantly higher at 92.7% in the low CONUT group, compared to a rate of 81.0% in the high CONUT group (p=0.0016). The five-year CSS was 71.2% in the low PNI group and 92.3% in the high PNI group, which showed a significant difference (p=0.0155). A multivariate analysis showed that lymph node metastasis and the CONUT score were independent risk factors for CSS. Conclusion This study suggested that the CONUT score is a strong independent predictor of the survival among CRC patients.

引用

页数：13

共 34 条

[1]

Tumour T-lymphocyte subset infiltration and tumour recurrence following curative resection for colorectal cancer [J].