Randomized controlled trial comparing gastrectomy plus chemotherapy with chemotherapy alone in advanced gastric cancer with a single non-curable factor: Japan clinical oncology group study JCOG 0705 and korea gastric cancer association study KGCA01

被引:54
作者
Fujitani, Kazumasa [1 ]
Yang, Han-Kwang [2 ]
Kurokawa, Yukinori [1 ]
Park, Do Joong [3 ]
Tsujinaka, Toshimasa [1 ]
Park, Byung-Joo [4 ]
Fukuda, Haruhiko [5 ]
Noh, Sung Hoon [6 ]
Boku, Narikazu [7 ]
Bang, Yung-Jue [8 ]
Sasako, Mitsuru [9 ]
Lee, Jong-Inn [10 ]
机构
[1] Natl Osaka Med Ctr, Dept Surg, Chuo Ku, Osaka 5400006, Japan
[2] Seoul Natl Univ, Canc Res Inst, Dept Surg, Seoul, South Korea
[3] Seoul Natl Univ, Bundang Hosp, Dept Surg, Seoul, South Korea
[4] Seoul Natl Univ, Dept Prevent Med, Seoul, South Korea
[5] Natl Canc Ctr, Ctr Canc Control & Informat Serv, Tokyo 104, Japan
[6] Yonsei Univ, Severance Hosp, Dept Surg, Seoul 120749, South Korea
[7] Shizuoka Canc Ctr, Dept Gastrointestinal Oncol, Shizuoka, Japan
[8] Seoul Natl Univ, Dept Med Oncol, Seoul, South Korea
[9] Hyogo Med Coll, Dept Surg, Kobe, Hyogo, Japan
[10] Korea Canc Ctr, Dept Surg, Seoul, South Korea
关键词
gastrectomy; chemotherapy; advanced gastric cancer; non-curable factor; randomized controlled trial;
D O I
10.1093/jjco/hyn058
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A randomized controlled trial has started in both Japan and Korea to evaluate the role of gastrectomy in the management of incurable advanced gastric cancer (AGC). Patients with AGC diagnosed as having a single non-curable factor are randomized to gastrectomy plus chemotherapy or chemotherapy alone. Surgeons at 33 specialized centers in Japan and at 15 high-volume hospitals in Korea will recruit 330 patients. Primary end-point is overall survival, and secondary end-points are progression-free survival and adverse events associated with either gastrectomy or chemotherapy.
引用
收藏
页码:504 / 506
页数:3
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