Nerve xenograft transplantation - Immunosuppression with FK-506 and RS-61443

被引：20

作者：

Hebebrand, D ^{[1
]}

Zohman, G ^{[1
]}

Jones, NF ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,HAND CTR,LOS ANGELES,CA 90095

来源：

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME | 1997年 / 22B卷 / 03期

关键词：

D O I：

10.1016/S0266-7681(97)80391-9

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

An experimental model has been developed to study the potential transplantation of nerve xenografts using the newer immunosuppressive agents RS-61443 and FK-506. Sciatic nerve grafts of 2 cm were transplanted from donor Golden Syrian hamsters into a 0.5 cm gap in the sciatic nerve of recipient Lewis rats. Walking track analysis, somatosensory evoked potentials and histology demonstrated improved regeneration across the nerve xenografts that had been immunosuppressed with RS-61443 and FK-506 compared with non-immunosuppressed controls, but the function never approached that seen in control isografts, Regeneration across nerve xenografts immunosuppressed with FK-506 was better than xenografts immunosuppressed with RS-61443.

引用

页码：304 / 307

页数：4

共 42 条

[1] LOW-DOSE, SHORT-TERM CYCLOSPORINE-A DOES NOT PROTECT THE SCHWANN-CELLS OF ALLOGENEIC NERVE GRAFTS [J].