Critical assessment of the value of sputum neutrophils

被引：27

作者：

Gupta, Vandana ^{[1
]}

Singh, Dave ^{[1
]}

机构：

[1] Univ Manchester, Med Evaluat Unit, Univ Hosp S Manchester Fdn Trust, Manchester M23 9QZ, Lancs, England

来源：

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2013年 / 10卷 / 01期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; INDUCED AIRWAY INFLAMMATION; NECROSIS-FACTOR-ALPHA; LUNG-FUNCTION; CIRCULATING NEUTROPHILS; BRONCHOALVEOLAR LAVAGE; BRONCHIAL BIOPSIES; HEALTHY-SUBJECTS; COPD PATIENTS; EXACERBATIONS;

D O I：

10.3109/15412555.2013.766105

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Neutrophils are central to the pathogenesis of COPD, releasing a range of proinflammatory and tissue destructive mediators. Sputum neutrophil numbers are elevated in COPD patients compared to healthy controls. We critically appraise the potential of sputum neutrophils as a biomarker in COPD. We show that there is insufficient evidence to support the use of this biomarker to define a phenotype of patients with more severe disease characteristics or a different prognosis. However, sputum neutrophil measurements can be used to measure the effects of anti-inflammatory drugs for the treatment of COPD.

引用

收藏

页码：107 / 114

页数：8

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