Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis

被引：68

作者：

Bhatia, Saurabh ^{[1
]}

Rathee, Permender ^{[1
]}

Sharma, Kiran ^{[2
]}

Chaugule, B. B. ^{[3
]}

Kar, Nabanita ^{[4
]}

Bera, Tanmoy ^{[4
]}

机构：

[1] PDMCOP, Bahadurgarh 124507, Haryana, India

[2] Jamia Hamdard, Dept Pharmaceut Sci, New Delhi, India

[3] Pune Univ, Dept Bot, Pune, Maharashtra, India

[4] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 57卷

关键词：

Porphyra vietnamensis; Algae; Porphyran; Polysaccharides; Immunomodulatory; IMMUNOMODULATORY ACTIVITY; MACROPHAGES; LYMPHOCYTES; EXTRACT; ALGAE; MICE;

D O I：

10.1016/j.ijbiomac.2013.03.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Our investigation explores the immuno-efficiency of sulphated polysaccharides enriched Polphyra vietnamenis. Isolated polysaccharide fraction (17.1-25.8%) was characterized by FTIR and NMR spectroscopy which showed the presence of typical linear backbone structure called as porphyran. Oral administration of porphyran (200-500 mg/kg) evoked a significant (P <= 0.05) increase in weight of the thymus, spleen and lymphoid organ cellularity. The total leucocyte and lymphocyte count was increased significantly (P < 0.005). The increase in the percent neutrophil adhesion to nylon fibres as well as a dose-dependent increase in antibody titre values was observed. A decreased response to DTH reaction induced by SRBC was recorded. A potential phagocytic response was seen and significant changes were observed in the formation of formazone crystals. It also prevented myelosuppression in cyclophosphamide drug treated rats. The results indicated that P. vietnamenis possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：50 / 56

页数：7

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