Cell-Type Specific Features of Circular RNA Expression

被引：2034

作者：

Salzman, Julia ^{[1
]}

Chen, Raymond E. ^{[1
,2
]}

Olsen, Mari N. ^{[1
,2
]}

Wang, Peter L. ^{[1
]}

Brown, Patrick O. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

来源：

PLOS GENETICS | 2013年 / 9卷 / 09期

基金：

美国国家科学基金会;

关键词：

CYP24A1; MESSENGER-RNA; CYP27B1; GENE; TRANSCRIPTS; VDR; ASSOCIATION;

D O I：

10.1371/journal.pgen.1003777

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular RNA expression in Drosophila melanogaster and estimate that in humans, circular RNA may account for 1% as many molecules as poly(A) RNA. Analysis of data from the ENCODE consortium revealed that the repertoire of genes expressing circular RNA, the ratio of circular to linear transcripts for each gene, and even the pattern of splice isoforms of circular RNAs from each gene were cell-type specific. These results suggest that biogenesis of circular RNA is an integral, conserved, and regulated feature of the gene expression program.

引用

页数：15

共 36 条

[1]

Expression of VDR and CYP24A1 mRNA in human tumors [J].

Anderson, MG ;

Nakane, M ;

Ruan, XA ;

Kroeger, PE ;

Wu-Wong, JR .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2006, 57 (02) :234-240

[2]

During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles [J].

Bailleul, B .

NUCLEIC ACIDS RESEARCH, 1996, 24 (06) :1015-1019

[3]

Marked Increase in CYP24A1 Gene Expression in Human Papillary Thyroid Cancer [J].

Balla, Bernadett ;

Kosa, Janos P. ;

Tobias, Balint ;

Halaszlaki, Csaba ;

Takacs, Istvan ;

Horvath, Henrik ;

Speer, Gabor ;

Nagy, Zsolt ;

Horanyi, Janos ;

Jaray, Balazs ;

Szekely, Eszter ;

Lakatos, Peter .

THYROID, 2011, 21 (04) :459-460

[4]

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk [J].

Burd, Christin E. ;

Jeck, William R. ;

Liu, Yan ;

Sanoff, Hanna K. ;

Wang, Zefeng ;

Sharpless, Norman E. .

PLOS GENETICS, 2010, 6 (12) :1-15

[5]

Northern blotting of RNA denatured in glyoxal without buffer recirculation [J].

Burnett, WV .

BIOTECHNIQUES, 1997, 22 (04) :668-671

[6]

CIRCULAR TRANSCRIPTS OF THE TESTIS-DETERMINING GENE SRY IN ADULT-MOUSE TESTIS [J].

CAPEL, B ;

SWAIN, A ;

NICOLIS, S ;

HACKER, A ;

WALTER, M ;

KOOPMAN, P ;

GOODFELLOW, P ;

LOVELLBADGE, R .

CELL, 1993, 73 (05) :1019-1030

[7]

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data [J].

Cerami, Ethan ;

Gao, Jianjiong ;

Dogrusoz, Ugur ;

Gross, Benjamin E. ;

Sumer, Selcuk Onur ;

Aksoy, Buelent Arman ;

Jacobsen, Anders ;

Byrne, Caitlin J. ;

Heuer, Michael L. ;

Larsson, Erik ;

Antipin, Yevgeniy ;

Reva, Boris ;

Goldberg, Arthur P. ;

Sander, Chris ;

Schultz, Nikolaus .

CANCER DISCOVERY, 2012, 2 (05) :401-404

[8]

INITIATION OF PROTEIN-SYNTHESIS BY THE EUKARYOTIC TRANSLATIONAL APPARATUS ON CIRCULAR RNAS [J].

CHEN, CY ;

SARNOW, P .

SCIENCE, 1995, 268 (5209) :415-417

[9]

Chen CY, 1998, METH MOL B, V77, P355

[10]

CYP24A1 Is an Independent Prognostic Marker of Survival in Patients with Lung Adenocarcinoma [J].

Chen, Guoan ;

Kim, So Hee ;

King, Amanda N. ;

Zhao, Lili ;

Simpson, Robert U. ;

Christensen, Paul J. ;

Wang, Zhuwen ;

Thomas, Dafydd G. ;

Giordano, Thomas J. ;

Lin, Lin ;

Brenner, Dean E. ;

Beer, David G. ;

Ramnath, Nithya .

CLINICAL CANCER RESEARCH, 2011, 17 (04) :817-826

← 1 2 3 4 →