Donor-derived breast cancer in a bone marrow transplantation recipient

被引：14

作者：

Golfinopouloss, Vassilis ^{[1
]}

Pentheroudakis, George ^{[1
]}

Kamakari, Smaragda ^{[2
]}

Metaxa-Mariatou, Vasiliki ^{[2
]}

Pavlidis, Nicholas ^{[1
]}

机构：

[1] Ioannina Univ Hosp, Dept Med Oncol, Ioannina 45500, Greece

[2] Ctr Genet Anal & Res, Athens, Greece

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2009年 / 113卷 / 02期

关键词：

Breast cancer; Allogenic bone marrow transplantation; STEM-CELLS;

D O I：

10.1007/s10549-008-9922-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified radical mastectomy for invasive breast adenocarcinoma. Genetic analysis revealed chimeric cellular populations on both the tumour and normal tissues of the patient with preponderance of donor-derived cells. We conclude that the patient's epithelia had been repopulated by donor-derived hemopoietic stem cells which gave rise to a malignant mammary neoplasm several years later. The donor remains healthy to date. This case adds weight to the theory of pluripotent normal and neoplastic stem cell histogenesis and emphasizes the pivotal role of supporting host stroma in carcinogenesis.

引用

页码：211 / 213

页数：3

共 7 条

[1]

Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring [J].

Au, WY ;

Chan, EC ;

Pang, A ;

Lie, AKW ;

Liang, R ;

Yuen, APW ;

Shek, TWH ;

Kwong, YL .

BONE MARROW TRANSPLANTATION, 2004, 34 (11) :981-985

[2]

Stem cells and cancer: Evidence for bone marrow stem cells in epithelial cancers [J].

Han-Chen Li ;

Stoicov, Calin ;

Rogers, Arlin B. ;

Houghton, JeanMarie .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (03) :363-371

[3]

Gastric cancer originating from bone marrow-derived cells [J].

Houghton, J ;

Stoicov, C ;

Nomura, S ;

Rogers, AB ;

Carlson, J ;

Li, HC ;

Cai, X ;

Fox, JG ;

Goldenring, JR ;

Wang, TC .

SCIENCE, 2004, 306 (5701) :1568-1571

[4]

Pluripotency of mesenchymal stem cells derived from adult marrow [J].

Jiang, Yuehua ;

Jahagirdar, Balkrishna N. ;

Reinhardt, R. Lee ;

Schwartz, Robert E. ;

Keene, C. Dirk ;

Ortiz-Gonzalez, Xilma R. ;

Reyes, Morayma ;

Lenvik, Todd ;

Lund, Troy ;

Blackstad, Mark ;

Du, Jingbo ;

Aldrich, Sara ;

Lisberg, Aaron ;

Low, Walter C. ;

Lergaespada, David A. ;

Verfaillie, Catherine M. .

Nature, 2002, 418 (6893) :41-49

[5]

Beyond tumorigenesis:: cancer stem cells in metastasis [J].

Li, Feng ;

Tiede, Benjamin ;

Massague, Joan ;

Kang, Yibin .

CELL RESEARCH, 2007, 17 (01) :3-14

[6]

Applying the principles of stem-cell biology to cancer [J].

Pardal, R ;

Clarke, MF ;

Morrison, SJ .

NATURE REVIEWS CANCER, 2003, 3 (12) :895-902

[7]

Contribution of bone marrow-derived endothelial cells to human tumor vasculature [J].

Peters, BA ;

Diaz, LA ;

Polyak, K ;

Meszler, L ;

Romans, K ;

Guinan, EC ;

Antin, JH ;

Myerson, D ;

Hamilton, SR ;

Vogelstein, B ;

Kinzler, KW ;

Lengauer, C .

NATURE MEDICINE, 2005, 11 (03) :261-262

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