Effect of thrombin inhibitors and a glycoprotein IIb/IIIa receptor antagonist in an ex vivo human experimental thrombosis model

被引：5

作者：

Zokai, K ^{[1
]}

Piazolo, L ^{[1
]}

Harenberg, J ^{[1
]}

机构：

[1] Univ Hosp, Dept Med 1, D-68167 Mannheim, Germany

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2001年 / 27卷 / 05期

关键词：

thrombosis model; GPIIb/IIIa antagonist; thrombin inhibitors; blood coagulation; platelets;

D O I：

10.1055/s-2001-17963

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of new antithrombotic drugs to inhibit the blood coagulation system and to block receptors of platelets represents an important area of medical research. The results of the efficacy in animal models are of critical importance for the further development of these compounds for human use. The transferability of such data from animal to human species still remains controversial. The antithrombotic effects of direct thrombin inhibitors and a glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonist were investigated in an experimental thrombosis model using human blood in order to analyze the feasibility of such a model.

引用

页码：531 / 536

页数：6

共 28 条

[1]

AGUEJOUF O, 1995, ANN CARDIOL ANGEIOL, V44, P109

[2] In vitro effects of the platelet glycoprotein IIb/IIIa receptor antagonist c7E3 Fab on the activated clotting time [J].

Ammar, T ;

Scudder, LE ;

Coller, BS .

CIRCULATION, 1997, 95 (03) :614-617

[3] Randomized, placebo-controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction [J].

Brener, SJ ;

Barr, LA ;

Burchenal, JEB ;

Katz, S ;

George, BS ;

Jones, AA ;

Cohen, ED ;

Gainey, PC ;

White, HJ ;

Cheek, HB ;

Moses, JW ;

Moliterno, DJ ;

Effron, MB ;

Topol, EJ .

CIRCULATION, 1998, 98 (08) :734-741

[4] USE OF A MONOCLONAL-ANTIBODY DIRECTED AGAINST THE PLATELET GLYCOPROTEIN IIB/IIIA RECEPTOR IN HIGH-RISK CORONARY ANGIOPLASTY [J].

CALIFF, RM ;

SHADOFF, N ;

VALETT, N ;

BATES, E ;

GALEANA, A ;

KNOPF, W ;

SHAFTEL, J ;

BENDER, MJ ;

AVERSANO, T ;

RAQUENO, J ;

GURBEL, P ;

COWFER, J ;

COHEN, M ;

CROSS, P ;

BITTL, J ;

EDDINGS, K ;

TAYLOR, M ;

DEROSA, K ;

HATTEL, L ;

COOPER, L ;

ESHELMAN, B ;

FINTEL, D ;

NIEMYSKI, P ;

KLEIN, L ;

KENNEDY, H ;

THORNTON, T ;

KEREIAKES, D ;

MARTIN, L ;

ANDERSON, L ;

HIGBY, N ;

ELLIS, S ;

BREZINA, K ;

GEORGE, B ;

CHAPEKIS, A ;

SMITH, D ;

ANWAR, A ;

GERBER, TL ;

PRITCHARD, GL ;

MYLER, R ;

SHAW, R ;

MURPHY, M ;

WARD, K ;

MADIGAN, NP ;

BLANKENSHIP, J ;

HALBERT, M ;

FLANAGAN, C ;

TANNENBAUM, M ;

POLICH, M ;

STEVENSON, C ;

TCHENG, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (14) :956-961

[5] THROMBOSIS IN UNSTABLE ANGINA [J].

CHESEBRO, JH ;

FUSTER, V .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (03) :192-194

[6]

CHIERCHIA S, 1987, FASEB J, V46, P81

[7]

Coller BS, 1997, THROMB HAEMOSTASIS, V78, P730

[8]

DEGROOT PG, 1990, BRIT J HAEMATOL, V75, P308

[9] VENOUS THROMBOSIS GENERATION BY MEANS OF HIGH-INTENSITY FOCUSED ULTRASOUND [J].

DELONMARTIN, C ;

VOGT, C ;

CHIGNIER, E ;

GUERS, C ;

CHAPELON, JY ;

CATHIGNOL, D .

ULTRASOUND IN MEDICINE AND BIOLOGY, 1995, 21 (01) :113-119

[10] PHARMACOLOGICAL CHARACTERIZATION OF A NEW 4-AMIDINOPHENYL-ALANINE THROMBIN-INHIBITOR (CRC-220) [J].

DICKNEITE, G ;

SEIFFGE, D ;

DIEHL, KH ;

REERS, M ;

CZECH, J ;

WEINMANN, E ;

HOFFMANN, D ;

STUBER, T .

THROMBOSIS RESEARCH, 1995, 77 (04) :357-368

← 1 2 3 →