Effects of degree of carboxymethylation on physicochemical and biological properties of pachyman

被引：78

作者：

Wang, Yongjiang ^{[1
,2
]}

Mo, Qing ^{[1
,2
]}

Li, Zenan ^{[1
,2
]}

Lai, Hongwu ^{[2
]}

Lou, Jian ^{[2
]}

Liu, Shiwang ^{[2
]}

Mao, Jianwei ^{[1
,2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China

[2] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Key Lab Agr Prod Chem & Biol Proc Technol Zhejian, Hangzhou 310023, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Pachyman; Carboxymethylation; DS; Properties; ANTIOXIDANT ACTIVITY; PORIA-COCOS; POLYSACCHARIDE FRACTIONS; DIETARY FIBER; BETA-GLUCAN; DERIVATIVES; SULFATES; CHITOSAN;

D O I：

10.1016/j.ijbiomac.2012.08.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Polysaccharides (pachyman) extracted from Poria cocos sclerotium were chemically modified by carboxymethylation and the effects on the structural and biological properties of the polysaccharides were investigated as a function of the degree of carboxymethylation. The degree of substitution (DS) of five carboxymethylated pachyman, coded as CMP1/CMP2/CMP3/CMP4/ CMP5, was determined to be 0.44-0.88. The structures were confirmed by FT-IR and their weight-average molecular masses (Mw) were obtained by SEC-LLS. Experimental results showed that derivatives were effective in anti-oxidation and bile acid binding in a dose dependent way. Furthermore, their water solubility and biological activities were improved with the increase of DS. Therefore, results proved that the carboxymethylation of pachyman effectively enhanced their potential biological properties. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1052 / 1056

页数：5

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