Ground-Based Facilities for Simulation of Microgravity: Organism-Specific Recommendations for Their Use, and Recommended Terminology

被引：346

作者：

Herranz, Raul ^{[1
]}

Anken, Ralf ^{[2
,3
]}

Boonstra, Johannes ^{[4
]}

Braun, Markus ^{[5
]}

Christianen, Peter C. M. ^{[6
]}

de Geest, Maarten ^{[4
]}

Hauslage, Jens ^{[2
]}

Hilbig, Reinhard ^{[3
]}

Hill, Richard J. A. ^{[7
]}

Lebert, Michael ^{[8
]}

Javier Medina, F. ^{[1
]}

Vagt, Nicole ^{[5
]}

Ullrich, Oliver ^{[9
]}

van Loon, Jack J. W. A. ^{[10
,11
,12
,13
]}

Hemmersbach, Ruth ^{[2
]}

机构：

[1] CSIC, Ctr Invest Biol, E-28040 Madrid, Spain

[2] German Aerosp Ctr DLR, Inst Aerosp Med, Cologne, Germany

[3] Univ Stuttgart Hohenheim, Inst Zool, D-70599 Stuttgart, Germany

[4] Univ Utrecht, Dept Biol, Fac Sci, Utrecht, Netherlands

[5] Univ Bonn, Inst Mol Physiol & Biotechnol Plants, Bonn, Germany

[6] Radboud Univ Nijmegen, Inst Mol & Mat, High Field Magnet Lab, NL-6525 ED Nijmegen, Netherlands

[7] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England

[8] Univ Erlangen Nurnberg, Dept Biol, Erlangen, Germany

[9] Univ Zurich, Fac Med, Inst Anat, Zurich, Switzerland

[10] Univ Amsterdam, Dutch Expt Support Ctr DESC ACTA, Amsterdam, Netherlands

[11] Vrije Univ Amsterdam, Amsterdam, Netherlands

[12] Res Inst MOVE, Dept Oral Cell Biol, Amsterdam, Netherlands

[13] European Space Agcy, TEC MMG, Estec, NL-2200 AG Noordwijk, Netherlands

来源：

ASTROBIOLOGY | 2013年 / 13卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

2-D clinostat; 3-D clinostat; Gravity; Magnetic levitation; Random positioning machine; Simulated microgravity; Space biology; INTERNATIONAL-SPACE-STATION; SPANISH-SOYUZ-MISSION; SHORT-TERM EXPOSURE; CELL-CYCLE CONTROL; CHARA RHIZOIDS; MODELED MICROGRAVITY; GRAVITATIONAL-FIELD; GENE-EXPRESSION; GROWTH; GRAVITY;

D O I：

10.1089/ast.2012.0876

中图分类号：

P1 [天文学];

学科分类号：

070403 [天体物理学];

摘要：

Research in microgravity is indispensable to disclose the impact of gravity on biological processes and organisms. However, research in the near-Earth orbit is severely constrained by the limited number of flight opportunities. Ground-based simulators of microgravity are valuable tools for preparing spaceflight experiments, but they also facilitate stand-alone studies and thus provide additional and cost-efficient platforms for gravitational research. The various microgravity simulators that are frequently used by gravitational biologists are based on different physical principles. This comparative study gives an overview of the most frequently used microgravity simulators and demonstrates their individual capacities and limitations. The range of applicability of the various ground-based microgravity simulators for biological specimens was carefully evaluated by using organisms that have been studied extensively under the conditions of real microgravity in space. In addition, current heterogeneous terminology is discussed critically, and recommendations are given for appropriate selection of adequate simulators and consistent use of nomenclature.

引用

页码：1 / 17

页数：17

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