Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

被引：191

作者：

Degterev, A. ^{[1
]}

Maki, J. L. ^{[1
]}

Yuan, J. ^{[2
]}

机构：

[1] Tufts Univ, Dept Biochem, Boston, MA 02111 USA

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2013年 / 20卷 / 02期

关键词：

TARGET;

D O I：

10.1038/cdd.2012.133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

页码：366 / 366

页数：1

共 6 条

[1]

A novel role for RIP1 kinase in mediating TNFα production [J].

Christofferson, D. E. ;

Li, Y. ;

Hitomi, J. ;

Zhou, W. ;

Upperman, C. ;

Zhu, H. ;

Gerber, S. A. ;

Gygi, S. ;

Yuan, J. .

CELL DEATH & DISEASE, 2012, 3 :e320-e320

[2]

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury [J].

Degterev A. ;

Huang Z. ;

Boyce M. ;

Li Y. ;

Jagtap P. ;

Mizushima N. ;

Cuny G.D. ;

Mitchison T.J. ;

Moskowitz M.A. ;

Yuan J. .

Nature Chemical Biology, 2005, 1 (2) :112-119

[3]

Identification of RIP1 kinase as a specific cellular target of necrostatins [J].

Degterev, Alexei ;

Hitomi, Junichi ;

Germscheid, Megan ;

Ch'en, Irene L. ;

Korkina, Olga ;

Teng, Xin ;

Abbott, Derek ;

Cuny, Gregory D. ;

Yuan, Chengye ;

Wagner, Gerhard ;

Hedrick, Stephen M. ;

Gerber, Scott A. ;

Lugovskoy, Alexey ;

Yuan, Junying .

NATURE CHEMICAL BIOLOGY, 2008, 4 (05) :313-321

[4]

PROGRAMMED NECROSIS: FROM MOLECULES TO HEALTH AND DISEASE [J].

Galluzzi, Lorenzo ;

Vanden Berghe, Tom ;

Vanlangenakker, Nele ;

Buettner, Sabrina ;

Eisenberg, Tobias ;

Vandenabeele, Peter ;

Madeo, Frank ;

Kroemer, Guido .

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 289, 2011, 289 :1-35

[5]

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy [J].

Muller, AJ ;

DuHadaway, JB ;

Donover, PS ;

Sutanto-Ward, E ;

Prendergast, GC .

NATURE MEDICINE, 2005, 11 (03) :312-319

[6]

Structure-activity relationship study of novel necroptosis inhibitors [J].

Teng, X ;

Degterev, A ;

Jagtap, P ;

Xing, XC ;

Choi, S ;

Denu, R ;

Yuan, JY ;

Cuny, GD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (22) :5039-5044

← 1 →