Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

被引：345

作者：

Chauveau, Fabien ^{[1
,2
]}

Boutin, Herve ^{[3
]}

Van Camp, Nadja ^{[1
,2
]}

Dolle, Frederic ^{[1
]}

Tavitian, Bertrand ^{[1
,2
]}

机构：

[1] CEA, Serv Hosp Frederic Joliot, Inst Imagerie BioMed, Lab Imagerie Mol Expt, F-91406 Orsay, France

[2] Univ Paris 11, INSERM, U803, F-91405 Orsay, France

[3] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2008年 / 35卷 / 12期

关键词：

Neuroinflammation; PET; C-11]PK11195; Peripheral benzodiazepine receptor (PBR); Translocator protein 18kDa (TSPO);

D O I：

10.1007/s00259-008-0908-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [C-11]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radio-labelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [C-11]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents.

引用

页码：2304 / 2319

页数：16

共 151 条

[1] Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage [J].

Akopov, SE ;

Simonian, NA ;

Grigorian, GS .

STROKE, 1996, 27 (10) :1739-1743

[2] Blood flow dependence of the intratumoral distribution of peripheral benzodiazepine receptor binding in intact mouse fibrosarcoma [J].

Amitani, Misato ;

Zhang, Ming-Rong ;

Noguchi, Junko ;

Kumata, Katsushi ;

ito, Takeh Ito ;

Takai, Nobuhiko ;

Suzuki, Kazutoshi ;

Hosoi, Rie ;

Inoue, Osamu .

NUCLEAR MEDICINE AND BIOLOGY, 2006, 33 (08) :971-975

[3]

ANDERSON AN, 2007, RNEUROIMAGE, V36, P28

[4] Toll-like receptor 2 signaling in response to brain injury: An innate bridge to neuroinflammation [J].

Babcock, Alicia A. ;

Wirenfeldt, Martin ;

Holm, Thomas ;

Nielsen, Helle H. ;

Dissing-Olesen, Lasse ;

Toft-Hansen, Henrik ;

Millward, Jason M. ;

Landmann, Regine ;

Rivest, Serge ;

Finsen, Bente ;

Owens, Trevor .

JOURNAL OF NEUROSCIENCE, 2006, 26 (49) :12826-12837

[5] Innate and adaptive immune responses of the central nervous system [J].

Bailey, SL ;

Carpentier, PA ;

McMahon, EJ ;

Begolka, WS ;

Miller, SD .

CRITICAL REVIEWS IN IMMUNOLOGY, 2006, 26 (02) :149-188

[6] Visualising microglial activation in vivo [J].

Banati, RB .

GLIA, 2002, 40 (02) :206-217

[7] The peripheral benzodiazepine binding site in the brain in multiple sclerosis -: Quantitative in vivo imaging of microglia as a measure of disease activity [J].

Banati, RB ;

Newcombe, J ;

Gunn, RN ;

Cagnin, A ;

Turkheimer, F ;

Heppner, F ;

Price, G ;

Wegner, F ;

Giovannoni, G ;

Miller, DH ;

Perkin, GD ;

Smith, T ;

Hewson, AK ;

Bydder, G ;

Kreutzberg, GW ;

Jones, T ;

Cuzner, ML ;

Myers, R .

BRAIN, 2000, 123 :2321-2337

[8] MR molecular imaging of early endothelial activation in focal ischemia [J].

Barber, PA ;

Foniok, T ;

Kirk, D ;

Buchan, AM ;

Laurent, S ;

Boutry, S ;

Muller, RN ;

Hoyte, L ;

Tomanek, B ;

Tuor, UI .

ANNALS OF NEUROLOGY, 2004, 56 (01) :116-120

[9]

BEAL MF, 1991, J NEUROSCI, V11, P1649

[10] Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration [J].

Belloli, S ;

Moresco, RM ;

Matarrese, M ;

Biella, G ;

Sanvito, F ;

Simonelli, P ;

Turolla, E ;

Olivieri, S ;

Cappelli, A ;

Vomero, S ;

Galli-Kienle, M ;

Fazio, F .

NEUROCHEMISTRY INTERNATIONAL, 2004, 44 (06) :433-440

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