Folding alphabets

被引：76

作者：

Chan, HS

机构：

[1] Univ Toronto, Dept Biochem, Fac Med, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Med Genet & Microbiol, Fac Med, Toronto, ON M5S 1A8, Canada

来源：

NATURE STRUCTURAL BIOLOGY | 1999年 / 6卷 / 11期

关键词：

D O I：

10.1038/14876

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new computational approach optimizes searches for reduced protein folding alphabets that use fewer than 20 types of amino acids. The predicted optimal five-letter alphabet happens to be in agreement with the suggestive results of a recent experiment, but whether highly reduced alphabets are sufficient for truly protein-like properties remains an open experimental question.

引用

页码：994 / 996

页数：3

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