Complex regulation of the BRCA1 gene

被引：127

作者：

Xu, CF

Chambers, JA

Solomon, E

机构：

[1] Div. of Med. and Molecular Genetics, UMDS, Guy's Hospital

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1997年 / 272卷 / 34期

关键词：

D O I：

10.1074/jbc.272.34.20994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression of the BRCA1 gene is under complex regulation. First, its transcription is under the control of two promoters generating two distinct transcripts alpha and beta, and second, promoter alpha is shared with the adjacent NBR2 gene and is bi-directional, Both promoter alpha and promoter beta are responsive: to estrogen stimulation. We also discerned that there are striking differences in both the genomic organization and immediate cis-control elements of the BRCA1 gene between humans and mice.

引用

页码：20994 / 20997

页数：4

共 28 条

[1]

Ausubel F.M., 1991, CURRENT PROTOCOLS MO

[2] A HUMAN BRCA1 GENE KNOCKOUT [J].

BOYD, M ;

HARRIS, F ;

MCFARLANE, R ;

DAVIDSON, HR ;

BLACK, DM .

NATURE, 1995, 375 (6532) :541-542

[3]

Brown MA, 1996, ONCOGENE, V12, P2507

[4] A NOVEL GENE ENCODING A B-BOX PROTEIN WITHIN THE BRCA1 REGION AT 17Q21.1 [J].

CAMPBELL, IG ;

NICOLAI, HM ;

FOULKES, WD ;

SENGER, G ;

STAMP, GW ;

ALLAN, G ;

BOYER, C ;

JONES, K ;

BAST, RC ;

SOLOMON, E ;

TROWSDALE, J ;

BLACK, DM .

HUMAN MOLECULAR GENETICS, 1994, 3 (04) :589-594

[5] Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene [J].

Chambers, JA ;

Solomon, E .

GENOMICS, 1996, 38 (03) :305-313

[6] CONTROL OF BREAST-CANCER CELL-GROWTH BY STEROIDS AND GROWTH-FACTORS - INTERACTIONS AND MECHANISMS [J].

FREISS, G ;

PREBOIS, C ;

VIGNON, F .

BREAST CANCER RESEARCH AND TREATMENT, 1993, 27 (1-2) :57-68

[7] BRCA1 MUTATIONS IN PRIMARY BREAST AND OVARIAN CARCINOMAS [J].

FUTREAL, PA ;

LIU, QY ;

SHATTUCKEIDENS, D ;

COCHRAN, C ;

HARSHMAN, K ;

TAVTIGIAN, S ;

BENNETT, LM ;

HAUGENSTRANO, A ;

SWENSEN, J ;

MIKI, Y ;

EDDINGTON, K ;

MCCLURE, M ;

FRYE, C ;

WEAVERFELDHAUS, J ;

DING, W ;

GHOLAMI, Z ;

SODERKVIST, P ;

TERRY, L ;

JHANWAR, S ;

BERCHUCK, A ;

IGLEHART, JD ;

MARKS, J ;

BALLINGER, DG ;

BARRETT, JC ;

SKOLNICK, MH ;

KAMB, A ;

WISEMAN, R .

SCIENCE, 1994, 266 (5182) :120-122

[8] ACTIVATION OF THE OVALBUMIN GENE BY THE ESTROGEN-RECEPTOR INVOLVES THE FOS-JUN COMPLEX [J].

GAUB, MP ;

BELLARD, M ;

SCHEUER, I ;

CHAMBON, P ;

SASSONECORSI, P .

CELL, 1990, 63 (06) :1267-1276

[9] Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities [J].

Gowen, LC ;

Johnson, BL ;

Latour, AM ;

Sulik, KK ;

Koller, BH .

NATURE GENETICS, 1996, 12 (02) :191-194

[10]

GUDAS JM, 1995, CANCER RES, V55, P4561

← 1 2 3 →