Deconstructing the hematopoietic stem cell niche: revealing the therapeutic potential

被引:8
作者
Adams, Gregor B. [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Ctr Stem Cell & Regenerat Med, Los Angeles, CA 90033 USA
关键词
bone marrow; hematopoietic stem cell; microenvironment; niche; osteoblast; parathyroid hormone;
D O I
10.2217/17460751.3.4.523
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Development of the hematopoietic system is a stage-specific process where the bone marrow eventually becomes the principal source of hematopoiesis in the adult mammalian organism. Sustained hematopoiesis in the bone marrow, however, depends on the self renewal of the resident hematopoietic stem cells (HSCs). The region where these HSCs are hypothesized to self renew is called the stem cell 'niche.' Recent studies have identified components of the HSC niche in the bone marrow, including cells of the osteoblastic lineage, extracellular matrix molecules and molecular signaling interactions between the stem cells and niche cells. Specific pharmacological targeting of these niche components has led to beneficial HSC effects, demonstrating a new therapeutic approach where stem cell function is altered through targeting of the niche.
引用
收藏
页码:523 / 530
页数:8
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