HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1

被引：9

作者：

Puliti, A

Cinti, R

Betsos, N

Romeo, G

Ceccherini, I

机构：

[1] Ist Giannina Gaslini, Genet Mol Lab, I-16148 Genoa, Italy

[2] Univ Pisa, Dipartimento Sci Uomo & Ambiente, I-56100 Pisa, Italy

[3] IARC, Genet Canc Susceptibil Unit, Lyon, France

[4] Univ Genoa, Dipartimento Oncol Biol & Genet, I-16126 Genoa, Italy

来源：

CYTOGENETICS AND CELL GENETICS | 1999年 / 84卷 / 1-2期

关键词：

D O I：

10.1159/000015234

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1 --> p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3D1 and human 2p13.1 --> p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX 11L1 (Tlx2).

引用

页码：115 / 117

页数：3

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