The Brain Activity Map Project and the Challenge of Functional Connectomics

被引：370

作者：

Alivisatos, A. Paul ^{[2
,3
]}

Chun, Miyoung ^{[4
]}

Church, George M. ^{[5
,6
]}

Greenspan, Ralph J. ^{[7
]}

Roukes, Michael L. ^{[8
,9
,10
,11
]}

Yuste, Rafael ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, HHMI, Kavli Inst Brain Sci, New York, NY 10027 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[4] Kavli Fdn, Oxnard, CA 93030 USA

[5] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Wyss Inst, Boston, MA 02115 USA

[7] Univ Calif San Diego, Kavli Inst Brain & Mind, La Jolla, CA 92093 USA

[8] CALTECH, Kavli Nanosci Inst, Pasadena, CA 91125 USA

[9] CALTECH, Dept Phys, Pasadena, CA 91125 USA

[10] CALTECH, Dept Appl Phys, Pasadena, CA 91125 USA

[11] CALTECH, Dept Bioengn, Pasadena, CA 91125 USA

来源：

NEURON | 2012年 / 74卷 / 06期

关键词：

NEURONS; NEOCORTEX; NETWORK; CALCIUM;

D O I：

10.1016/j.neuron.2012.06.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain Activity Map Project, aimed at reconstructing the full record of neural activity across complete neural circuits. This technological challenge could prove to be an invaluable step toward understanding fundamental and pathological brain processes.

引用

页码：970 / 974

页数：5

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