Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control

被引：147

作者：

Cohen, Ted ^{[1
,2
,3
]}

van Helden, Paul D. ^{[4
]}

Wilson, Douglas ^{[5
]}

Colijn, Caroline ^{[6
]}

McLaughlin, Megan M. ^{[1
]}

Abubakar, Ibrahim ^{[7
,8
]}

Warren, Robin M. ^{[4
]}

机构：

[1] Brigham & Womens Hosp, Div Global Hlth Equ, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Ctr Communicable Dis Dynam, Boston, MA 02115 USA

[4] Univ Stellenbosch, Div Mol Biol & Human Genet, Ctr Mol & Cellular Biol,Fac Med & Hlth Sci, DST NRF Ctr Excellence Biomed TB Res,MRC, ZA-7505 Tygerberg, South Africa

[5] Univ KwaZulu Natal, Edendale Hosp, Dept Med, Durban, South Africa

[6] Univ London Imperial Coll Sci Technol & Med, Dept Math, London, England

[7] Univ E Anglia, Norwich Med Sch, Dept Med, Norwich NR4 7TJ, Norfolk, England

[8] Hlth Protect Agcy, TB Sect, London, England

来源：

CLINICAL MICROBIOLOGY REVIEWS | 2012年 / 25卷 / 04期

基金：

英国工程与自然科学研究理事会; 美国国家卫生研究院;

关键词：

DRUG-RESISTANT TUBERCULOSIS; RESUSCITATION-PROMOTING FACTORS; ISONIAZID PREVENTIVE THERAPY; NON-BEIJING STRAINS; RPF-LIKE GENES; MULTIDRUG-RESISTANT; EXOGENOUS REINFECTION; MOLECULAR EPIDEMIOLOGY; PULMONARY TUBERCULOSIS; MULTIPLE STRAINS;

D O I：

10.1128/CMR.00021-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Numerous studies have reported that individuals can simultaneously harbor multiple distinct strains of Mycobacterium tuberculosis. To date, there has been limited discussion of the consequences for the individual or the epidemiological importance of mixed infections. Here, we review studies that documented mixed infections, highlight challenges associated with the detection of mixed infections, and discuss possible implications of mixed infections for the diagnosis and treatment of patients and for the community impact of tuberculosis control strategies. We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections.

引用

页码：708 / +

页数：13

共 113 条

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