Interferon β-modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion

被引：34

作者：

Yasuda, CL

Al-Sabbagh, A

Oliveira, EC

Diaz-Bardales, BM

Garcia, AA

Santos, LMB ^{[1
]}

机构：

[1] UNICAMP, Inst Biol, Dept Microbiol & Immunol, Neuroimmunol Unit, BR-13083970 Campinas, SP, Brazil

[2] Biogen Inc, Cambridge, MA 02142 USA

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1999年 / 28卷 / 2-3期

关键词：

D O I：

10.3109/08820139909061141

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanism of action underlying the beneficial effect of IFN beta in Multiple Sclerosis is poorly understood. Experimental Autoimmune Encephalomyelitis (EAE) is the experimental model for Multiple Sclerosis; therefore, we investigated the effects of recombinant mouse IFN beta on the severity of EAE induced in SJL mice and on cytokine production by Th1 and Th2 lymphocytes. The results indicated that rmIFN beta reduced the disease activity with an I.P, dosage of 10,000 U/day every other day, and successfully treated EAE mice revealed reduced amounts of IFN gamma; no changes in the levels of IL4 were observed, although thera was a significant increase in IL10 and TGF beta production. Beneficial effects on EAE are associated with inhibition of inflammatory cytokines and stimulation of anti-inflammatory cytokines.

引用

页码：115 / 126

页数：12

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