The kinetics of S-transnitrosation -: A reversible second-order reaction

被引：86

作者：

Hogg, N ^{[1
]}

机构：

[1] Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53227 USA

来源：

ANALYTICAL BIOCHEMISTRY | 1999年 / 272卷 / 02期

关键词：

D O I：

10.1006/abio.1999.4199

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Transnitrosation between thiols and S-nitrosothiols has been suggested to be a mechanism of signal transduction. This kinetics of such reactions fit well to a reversible second-order model. Parameters derived from this model give both the forward and reverse rate constants and the equilibrium position at physiological temperature and pH. In addition, methods are shown for calculating the equilibrium distribution of the nitrosyl function group in mixtures of up to three thiols. (C) 1999 Academic Press.

引用

页码：257 / 262

页数：6

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