Origin, targeting, and function of the apicomplexan plastid

被引：112

作者：

Roos, DS ^{[1
]}

Crawford, MJ ^{[1
]}

Donald, RGK ^{[1
]}

Kissinger, JC ^{[1
]}

Klimczak, LJ ^{[1
]}

Striepen, B ^{[1
]}

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1369-5274(99)80075-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The discovery of a plastid in Plasmodium, Toxoplasma and related protozoan parasites provides a satisfying resolution to several long-standing mysteries: the mechanism of action for Various surprisingly effective antibiotics; the subcellular location of an enigmatic 35 kb episomal DNA; and the nature of an unusual intracellular structure containing multiple membranes. The apicomplexan plastid highlights the importance of lateral genetic transfer in evolution and provides an accessible system for the investigation of protein targeting to secondary endosymbiotic organelles. Combining molecular genetic identification of targeting signals with whole genome analysis promises to yield a complete picture of organellar metabolic pathways and new targets for drug design.

引用

收藏

页码：426 / 432

页数：7

相关论文

共 74 条

[1] PLASMODIUM - FINE STRUCTURE OF MALARIAL PARASITES [J].

AIKAWA, M .

EXPERIMENTAL PARASITOLOGY, 1971, 30 (02) :284-+

[2] Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the apicomplexa [J].

Ajioka, JW ;

Boothroyd, JC ;

Brunk, BP ;

Hehl, A ;

Hillier, L ;

Manger, ID ;

Marra, M ;

Overton, GC ;

Roos, DS ;

Wan, KL ;

Waterston, R ;

Sibley, LD .

GENOME RESEARCH, 1998, 8 (01) :18-28

[3] The genome sequence of Rickettsia prowazekii and the origin of mitochondria [J].

Andersson, SGE ;

Zomorodipour, A ;

Andersson, JO ;

Sicheritz-Pontén, T ;

Alsmark, UCM ;

Podowski, RM ;

Näslund, AK ;

Eriksson, AS ;

Winkler, HH ;

Kurland, CG .

NATURE, 1998, 396 (6707) :133-140

[4] THE GENE FAMILY ENCODING THE FUCOXANTHIN CHLOROPHYLL PROTEINS FROM THE BROWN ALGA MACROCYSTIS-PYRIFERA [J].

APT, KE ;

CLENDENNEN, SK ;

POWERS, DA ;

GROSSMAN, AR .

MOLECULAR & GENERAL GENETICS, 1995, 246 (04) :455-464

[5] INVIVO ACTIVITY OF THE MACROLIDE ANTIBIOTICS AZITHROMYCIN, ROXITHROMYCIN AND SPIRAMYCIN AGAINST TOXOPLASMA-GONDII [J].

ARAUJO, FG ;

SHEPARD, RM ;

REMINGTON, JS .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (06) :519-524

[6] Rifapentine is active in vitro and in vivo against Toxoplasma gondii [J].

Araujo, FG ;

Khan, AA ;

Remington, JS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (06) :1335-1337

[7] INHIBITION OF CYTOPLASMIC AND ORGANELLAR PROTEIN-SYNTHESIS IN TOXOPLASMA-GONDII - IMPLICATIONS FOR THE TARGET OF MACROLIDE ANTIBIOTICS [J].

BECKERS, CJM ;

ROOS, DS ;

DONALD, RGK ;

LUFT, BJ ;

SCHWAB, JC ;

CAO, Y ;

JOINER, KA .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (01) :367-376

[8] Mechanism of protein targeting to the chlorarachniophyte plastids and the evolution of complex plastids with four membranes - A hypothesis [J].

Bodyl, A .

BOTANICA ACTA, 1997, 110 (05) :395-400

[9]

BOOTHROYD JC, 1994, METHODS MOL GENET, V3, P1

[10] Prediction of complete gene structures in human genomic DNA [J].

Burge, C ;

Karlin, S .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 268 (01) :78-94

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