Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention A North American Perspective-2016 Update

被引：82

作者：

Angiolillo, Dominick J. ^{[1
]}

Goodman, Shaun G. ^{[2
,3
,4
]}

Bhatt, Deepak L. ^{[5
,6
]}

Eikelboom, John W. ^{[7
]}

Price, Matthew J. ^{[8
]}

Moliterno, David J. ^{[9
,10
]}

Cannon, Christopher P. ^{[11
]}

Tanguay, Jean-Francois ^{[12
]}

Granger, Christopher B. ^{[13
]}

Mauri, Laura ^{[11
]}

Holmes, David R. ^{[14
]}

Gibson, C. Michael ^{[15
]}

Faxon, David P. ^{[5
,6
]}

机构：

[1] Univ Florida, Coll Med Jacksonville, Div Cardiol, Jacksonville, FL USA

[2] Univ Toronto, St Michaels Hosp, Toronto, ON, Canada

[3] Canadian Heart Res Ctr, Toronto, ON, Canada

[4] Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada

[5] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA

[6] Harvard Med Sch, Boston, MA USA

[7] Thrombosis & Atherosclerosis Res Inst, Populat Hlth Res Inst, Dept Med, Hamilton, ON, Canada

[8] Scripps Clin, Div Cardiovasc Dis, La Jolla, CA 92037 USA

[9] Univ Kentucky, Div Cardiovasc Med, Lexington, KY 40506 USA

[10] Univ Kentucky, Gill Heart Inst, Lexington, KY 40506 USA

[11] Harvard Med Sch, Brigham & Womens Hosp, Harvard Clin Res Inst, Boston, MA USA

[12] Univ Montreal, Montreal Heart Inst, Dept Med, Montreal, PQ, Canada

[13] Duke Univ, Duke Clin Res Inst, Durham, NC USA

[14] Mayo Clin, Rochester, MN USA

[15] Beth Israel Deaconess Med Ctr, Dept Med, Div Cardiol, Boston, MA 02215 USA

来源：

CIRCULATION-CARDIOVASCULAR INTERVENTIONS | 2016年 / 9卷 / 11期

关键词：

anticoagulant; antiplatelet therapy; atrial fibrillation; hemorrhage; stent; thrombosis; DUAL ANTIPLATELET THERAPY; ELUTING STENT IMPLANTATION; HEART RHYTHM ASSOCIATION; BARE-METAL STENTS; ELEVATION MYOCARDIAL-INFARCTION; CARDIOLOGY WORKING GROUP; VITAMIN-K ANTAGONISTS; BIORESORBABLE VASCULAR SCAFFOLDS; GLYCOPROTEIN IIB/IIIA INHIBITOR; PROTHROMBIN COMPLEX CONCENTRATE;

D O I：

10.1161/CIRCINTERVENTIONS.116.004395

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The optimal antithrombotic treatment regimen for patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation is an emerging clinical problem. Currently, there is limited evidenced-based data on the optimal antithrombotic treatment regimen, including antiplatelet and anticoagulant therapies, for these high-risk patients with practice guidelines, thus, providing limited recommendations. Over the past years, expert consensus documents have provided guidance to clinicians on how to manage patients with atrial fibrillation undergoing percutaneous coronary intervention. Given the recent advancements in the field, the current document provides an updated opinion of selected North American experts from the United States and Canada on the treatment of patients with atrial fibrillation undergoing percutaneous coronary intervention. In particular, this document provides the current views on (1) embolic/stroke risk, (2) ischemic/thrombotic cardiac risk, and (3) bleeding risk, which are pivotal for discerning the choice of antithrombotic therapy. In addition, we describe the recent advances in pharmacology, stent designs, and clinical trials relevant to the field. Ultimately, we provide expert consensus-derived recommendations, using a pragmatic approach, on the management of patients with atrial fibrillation undergoing percutaneous coronary intervention.

引用

页数：26

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