RECKing MMP function: implications for cancer development

被引：96

作者：

Rhee, JS

Coussens, LM

机构：

[1] Univ Calif San Francisco, Med Scientist Training Program, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(02)02280-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer is a multistage process requiring progressive genetic and epigenetic changes in neoplastic and responding stromal cells. Many alterations that occur during the process of malignant progression are regulated by the matrix metalloproteinase (MMP) family of extracellular proteases and their endogenous inhibitors. Recent work has identified a new cell-surface inhibitor of MMPs - RECK. RECK regulates MMP-induced pericellular signaling cascades during embryogenesis and tumorigenesis. Homozygous loss of RECK results in embryonic lethality and attenuated tumor development in adults thus providing further support for an efficacious role for protease inhibitors as anticancer therapeutics.

引用

页码：209 / 211

页数：3

共 17 条

[1] Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation [J].