Abrogation of post-myeloablative chemotherapy neutropenia by ex-vivo expanded autologous CD34-positive cells

被引：136

作者：

Reiffers, J

Cailliot, C

Dazey, B

Attal, M

Caraux, J

Boiron, JM

机构：

[1] CHRU Bordeaux, Hop Haut Leveque, Pessac, France

[2] Estab Transfus Sanguine Aguitaine, Dept Cell Therapy, Bordeaux, France

[3] CHU Toulouse, Toulouse, France

[4] Amgen SA, Neuilly Sur Seine, France

来源：

LANCET | 1999年 / 354卷 / 9184期

关键词：

D O I：

10.1016/S0140-6736(99)03113-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We show that absolute and severe neutropenia after high-dose therapy with melphalan with or without total body irradiation can be abrogated by cells generated ex vivo. This may change the clinical practice of haematopoietic cell transplantation and high-dose chemotherapy because the morbidity and hospitalisation associated with neutropenia could be avoided or reduced.

引用

页码：1092 / 1093

页数：2

共 5 条

[1]

ANDREWS RG, 1997, BLOOD, V80, P405

[2]

ATTAL M, IN PRESS BAILLERES C

[3] RETRACTED: RECONSTITUTION OF HEMATOPOIESIS AFTER HIGH-DOSE CHEMOTHERAPY BY AUTOLOGOUS PROGENITOR CELLS GENERATED EX-VIVO (RETRACTED ARTICLE. SEE VOL 345, PG 64, 2001) [J].

BRUGGER, W ;

HEIMFELD, S ;

BERENSON, RJ ;

MERTELSANN, R ;

KANZ, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (05) :283-287

[4] Stem cell factor in combination with filgrastim after chemotherapy improves peripheral blood progenitor cell yield and reduces apheresis requirements in multiple myeloma patients:: A randomized, controlled trial [J].

Facon, T ;

Harousseau, JL ;

Maloisel, F ;

Attal, M ;

Odriozola, J ;

Alegre, A ;

Schroyens, W ;

Hulin, C ;

Schots, R ;

Marin, P ;

Guilhot, F ;

Granena, A ;

De Waele, M ;

Pigneux, A ;

Méresse, V ;

Clark, P ;

Reiffers, J .

BLOOD, 1999, 94 (04) :1218-1225

[5]

Williams SF, 1996, BLOOD, V87, P1687

← 1 →